TECR,TECRL dehydrogenate TOD-CoA to ST-CoA

Stable Identifier
R-HSA-548831
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
Synonyms
(2E)-octadecenoyl-CoA + H(+) + NADPH => NADP(+) + octadecanoyl-CoA, trans-octadec-2-enoyl-CoA + NADPH + H+ => stearoyl-CoA + NADP+
ReviewStatus
5/5
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TECR,TECRL dehydrogenate TOD-CoA to ST-CoA
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Trans-2,3-enoyl-CoA reductase (TECR) catalyzes the reaction of trans-octadec-2-enoyl-CoA and NADPH + H+ to form stearoyl-CoA and NADP+. This activity of TECR protein and its localization to the endoplasmic reticulum membrane was established in studies of transfected cells expressing the protein (Moon and Horton 2003).
Literature References
PubMed ID Title Journal Year
12482854 Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade

Horton, JD, Moon, YA

J Biol Chem 2003
Participants
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Output
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as an event of
Catalyst Activity

very-long-chain fatty acyl-CoA dehydrogenase activity of TECR,TECRL [endoplasmic reticulum membrane]

Physical Entity
TECR,TECRL [endoplasmic reticulum membrane] (Homo sapiens)
Activity
very-long-chain fatty acyl-CoA dehydrogenase activity (GO:0017099)
Orthologous Events
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Bos taurus)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Caenorhabditis elegans)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Canis familiaris)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Dictyostelium discoideum)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Drosophila melanogaster)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Gallus gallus)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Mus musculus)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Plasmodium falciparum)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Rattus norvegicus)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Saccharomyces cerevisiae)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Schizosaccharomyces pombe)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Sus scrofa)
TECR,TECRL dehydrogenate TOD-CoA to ST-CoA (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2010-03-15)
Reviewed
D'Eustachio, P  (2015-02-22)
Created
D'Eustachio, P  (2010-03-15)
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