Reactome | ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA

ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA

Stable Identifier

R-HSA-548814

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

H(+) + hexadecanoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA + CO2 + CoA, palmitoyl-CoA + malonyl-CoA => 3-oxooctadecanoyl-CoA (3-oxostearoyl-CoA) + CO2 + CoASH

ReviewStatus

5/5

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ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA

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The ER membrane-bound elongation of very long chain fatty acids proteins 3, 6 and 7 (ELOVL3,6,7) catalyse the condensation of palmitoyl-CoA (PALM-CoA) with malonyl-CoA (Mal-CoA) to form 3-oxooctadecanoyl-CoA (3OOD-CoA) (Shimamura et al. 2009, Ohno et al. 2010, Naganuma et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21959040	Biochemical characterization of the very long-chain fatty acid elongase ELOVL7 Naganuma, T, Sato, Y, Sassa, T, Ohno, Y, Kihara, A	FEBS Lett.	2011
19505953	Identification and characterization of a selective radioligand for ELOVL6 Shimamura, K, Takahashi, H, Kitazawa, H, Miyamoto, Y, Nagumo, A, Tang, C, Dean, D, Nagase, T, Sato, N, Tokita, S	J Biochem	2009
20937905	ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis Ohno, Y, Suto, S, Yamanaka, M, Mizutani, Y, Mitsutake, S, Igarashi, Y, Sassa, T, Kihara, A	Proc Natl Acad Sci U S A	2010