Deletions in the AXIN1 gene destabilize the destruction complex

Stable Identifier
R-HSA-5467345
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Deletions in the AXIN1 gene destabilize the destruction complex
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Deletions in the AXIN1 gene have been identified in 2 hepatocellular carcinoma cell lines. These deletions, which remove the N-terminal exons of the gene, compromise AXIN1 expression and result in elevated expression of a TCF-dependent reporter (Satoh et al, 2000, reviewed in Salahshor and Woodgett, 2005).
Literature References
PubMed ID Title Journal Year
15735151 The links between axin and carcinogenesis

Salahshor, S, Woodgett, JR

J. Clin. Pathol. 2005
10700176 AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

Miwa, N, Tokino, T, Furukawa, Y, Fujita, M, Daigo, Y, Nishiwaki, T, Nakamura, Y, Kato, T, Satoh, S, Kawasoe, T, Yamaoka, Y, Murata, M, Sasaki, Y, Ishiguro, H, Shimano, T, Imaoka, S

Nat. Genet. 2000
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Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2014-01-23)
Reviewed
Salahshor, S  (2014-05-12)
Woodgett, J  (2014-05-22)
Created
Rothfels, K  (2014-05-16)
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