Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CSF3 [extracellular region]
Stable Identifier
R-HSA-5432997
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
G-CSF, Granulocyte colony-stimulating factor
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF3 (G-CSF) (Homo sapiens)
CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
CSF3 dimer:CSF3R:LYN:JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
CSF3 dimer:2xCSF3R:LYN:JAK1 induces phosphorylation of JAK1 (Homo sapiens)
CSF3 dimer:2xCSF3R:LYN:JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:CSF3R:LYN:JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:STAT1,3,5 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-TYK2 binds and phosphorylates SHC1, GRB2, GAB2, and PTPN11 (SHP2) (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 (Homo sapiens)
CSF3 dimer:2xCSF3R:LYN:JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:CSF3R:LYN:JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
CSF3 dimer:CSF3R:LYN:JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
Inactivation of CSF3 (G-CSF) signaling (Homo sapiens)
SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 (Homo sapiens)
CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:STAT1,3,5 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer:p-4Y-CSF3R:LYN:p-Y-JAK1 [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 negatively regulates extracellular inflammatory mediators (Homo sapiens)
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
Other interleukin signaling (Homo sapiens)
CSF3 dimer:CSFR binds CSFR (Homo sapiens)
CSF3 dimer:2xCSF3R [plasma membrane] (Homo sapiens)
CSF3 dimer:CSF3R [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
CSF3 dimer:CSF3R [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
CSF3R binds CSF3 dimer (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
CSF3 dimer:CSF3R [plasma membrane] (Homo sapiens)
CSF3 dimer [extracellular region] (Homo sapiens)
CSF3 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P09919 CSF3
Gene Names
CSF3, C17orf33, GCSF
Chain
signal peptide:1-30, chain:31-207
Reference Genes
BioGPS Gene:1440 CSF3
COSMIC (genes):CSF3 CSF3
CTD Gene:1440 CSF3
dbSNP Gene:1440 Q8N4W3
ENSEMBL:ENSG00000108342 CSF3
HGNC:2438 CSF3
KEGG:hsa:1440 CSF3
Monarch:1440 CSF3
NCBI Gene:1440 CSF3
OMIM:138970 CSF3
UCSC:P09919 CSF3
Reference Transcript
RefSeq:NM_001178147.1 CSF3
RefSeq:NM_000759.3 CSF3
RefSeq:NM_172219.2 CSF3
RefSeq:NM_172220.2 CSF3
Other Identifiers
11729512_a_at
11729513_x_at
11729514_a_at
1334_s_at
1440
16833953
207442_PM_at
207442_at
3720676
3720677
3720678
3720679
3720680
3720682
3720683
3720684
3720685
3720686
3720687
3720688
3720689
3720690
8006999
A_14_P128877
A_23_P501754
A_33_P3222424
GE59652
GO:0002376
GO:0005102
GO:0005125
GO:0005130
GO:0005515
GO:0005576
GO:0005615
GO:0006355
GO:0006955
GO:0007165
GO:0008083
GO:0008284
GO:0019221
GO:0019899
GO:0030154
GO:0030838
GO:0030851
GO:0038158
GO:0043202
GO:0045471
GO:0045639
GO:0045944
GO:0048018
GO:0050731
GO:0051897
GO:0071222
GO:0071345
GO:0071682
GO:0098772
GO:0110053
HMNXSV003025460
ILMN_1697069
ILMN_1706852
ILMN_2322768
PH_hs_0000295
TC17000486.hg
TC17002194.hg
X03656_rna1_at
g4503078_3p_at
Participates
as a member of
IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)
as a component of
CSF3 dimer [extracellular region] (Homo sapiens)
Other forms of this molecule
CSF3 [lysosomal lumen]
CSF3 [endocytic vesicle lumen]
Inferred To
CSF3 [extracellular region]
(Bos taurus)
CSF3 [extracellular region]
(Canis familiaris)
CSF3 [extracellular region]
(Gallus gallus)
CSF3 [extracellular region]
(Sus scrofa)
Ghost homologue of CSF3 [extracellular region]
(Drosophila melanogaster)
csf3 [extracellular region]
(Xenopus tropicalis)
Csf3 [extracellular region]
(Mus musculus)
Csf3 [extracellular region]
(Rattus norvegicus)
Homologues of CSF3 [extracellular region]
(Sus scrofa)
Cross References
ENSEMBL
ENSG00000108342
,
ENST00000394148
,
ENST00000394149
,
ENSP00000225474
,
ENST00000225474
,
ENSP00000377704
,
ENSP00000377705
OpenTargets
ENSG00000108342
GeneCards
CSF3
HPA
ENSG00000108342-CSF3
PRO
P09919
Pharos - Targets
P09919
GlyGen
P09919
PDB
1RHG
,
1PGR
,
2D9Q
,
5ZO6
,
1GNC
,
1CD9
,
5GW9
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text