Reactome | AKR dimers reduce AFBDHO to AFBDOH

AKR dimers reduce AFBDHO to AFBDOH

Stable Identifier

R-HSA-5423637

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Aflatoxin B1 aldehyde reductases (AKR7A2, AKR7A3 and AKR7L) are dimeric, cytosolic, NADPH-dependent enzymes able to catalyse the reduction of aflatoxin B1 dialdehyde (AFBDHO) to aflatoxin B1-6,8-dialcohol (AFBDOH) (Ellis et al. 2003, Bodreddigari et al. 2008, Ireland et al. 1998, Guengerich et al. 2001). AKRs can turnover a vast range of substrates, including drugs, carcinogens, and reactive aldehydes. They play central roles in the metabolism of these agents, leading to either their bioactivation or detoxication (Jin & Penning 2007). The dialcohol is excreted in urine by conjugation with glucuronide (not shown here).

Literature References

PubMed ID	Title	Journal	Year
12727802	Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter Ellis, EM, Slattery, CM, Hayes, JD	Carcinogenesis	2003
18416522	Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3 Bodreddigari, S, Jones, LK, Egner, PA, Groopman, JD, Sutter, CH, Roebuck, BD, Guengerich, FP, Kensler, TW, Sutter, TR	Chem. Res. Toxicol.	2008
16970545	Aldo-keto reductases and bioactivation/detoxication Jin, Y, Penning, TM	Annu. Rev. Pharmacol. Toxicol.	2007
9576847	Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase Ireland, LS, Harrison, DJ, Neal, GE, Hayes, JD	Biochem. J.	1998
11409944	Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases Guengerich, FP, Cai, H, McMahon, M, Hayes, JD, Sutter, TR, Groopman, JD, Deng, Z, Harris, TM	Chem. Res. Toxicol.	2001