Reactome | RXRA:PPARD binds FABP5:atRA

RXRA:PPARD binds FABP5:atRA

Stable Identifier

R-HSA-5422942

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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In the nucleus, all-trans-retinoic acid (atRA), bounds to epidermal fatty acid-binding protein (FABP5), is transferred to the heterodimeric complex of retinoic acid receptor alpha RXRA) and peroxisome proliferator-activated receptor delta (PPARD). When bound to PPARD, atRA can significantly increase the expression of proteins involved in fatty acid oxidation and energy metabolism via its induction of PPARD (Wolf 2010, Amengual et al. 2012, Noy 2013).

Literature References

PubMed ID	Title	Journal	Year
20042001	Retinoic acid activation of peroxisome proliferation-activated receptor delta represses obesity and insulin resistance Wolf, G	Nutr. Rev.	2010
22871568	Induction of carnitine palmitoyl transferase 1 and fatty acid oxidation by retinoic acid in HepG2 cells Amengual, J, Petrov, P, Bonet, ML, Ribot, J, Palou, A	Int. J. Biochem. Cell Biol.	2012
23991366	The one-two punch: Retinoic acid suppresses obesity both by promoting energy expenditure and by inhibiting adipogenesis Noy, N	Adipocyte	2013