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MRPL40 [mitochondrial inner membrane]
Stable Identifier
R-HSA-5368222
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
39S ribosomal protein L40, mitochondrial, RM40_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Mitochondrial translation (Homo sapiens)
Mitochondrial translation elongation (Homo sapiens)
55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA at A-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
Peptide transfer from P-site to A-site (peptide bond formation) (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA at A-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA:TUFM:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA:TUFM:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA at P-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
Mitochondrial translation initiation (Homo sapiens)
39S subunit binds 28S subunit:mRNA:fMet-tRNA (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
Mitochondrial translation termination (Homo sapiens)
55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA (Homo sapiens)
55S ribosome:MRRF:GFM2:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:MRRF [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
Hydrolysis of GTP and dissociation of 28S and 39S subunits (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:MRRF:GFM2:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
MRRF binds 55S ribosome:mRNA:tRNA (Homo sapiens)
55S ribosome:mRNA:tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:MRRF [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA at P-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL40 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NQ50 MRPL40
Gene Names
MRPL40, NLVCF, URIM
Chain
transit peptide:1-46, chain:47-206
Reference Genes
BioGPS Gene:64976 MRPL40
COSMIC (genes):MRPL40 MRPL40
CTD Gene:64976 MRPL40
dbSNP Gene:64976 MRPL40
ENSEMBL:ENSG00000185608 MRPL40
HGNC:14491 MRPL40
KEGG:hsa:64976 MRPL40
Monarch:64976 MRPL40
NCBI Gene:64976 MRPL40
OMIM:605089 MRPL40
UCSC:Q9NQ50 MRPL40
Reference Transcript
RefSeq:NM_003776.3 MRPL40
Other Identifiers
11717987_a_at
16927040
203152_PM_at
203152_at
32745_at
3936889
3936890
3936891
3936892
3936893
3936895
3936896
3936897
64976
8071206
A_24_P228667
GE54257
GO:0003723
GO:0005515
GO:0005634
GO:0005730
GO:0005739
GO:0005743
GO:0005761
GO:0005762
GO:0005840
GO:0009653
GO:0032543
GO:0043226
GO:1990904
HMNXSV003050652
ILMN_1687403
PH_hs_0019958
TC22000044.hg
g4505402_3p_at
Participates
as a component of
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
Inferred To
mRpL40 [mitochondrial inner membrane]
(Drosophila melanogaster)
mrpl40 [mitochondrial inner membrane]
(Danio rerio)
Mrpl40 [mitochondrial inner membrane]
(Mus musculus)
Mrpl40 [mitochondrial inner membrane]
(Rattus norvegicus)
mrpl-40 [mitochondrial inner membrane]
(Caenorhabditis elegans)
MRPL40 [mitochondrial inner membrane]
(Bos taurus)
MRPL40 [mitochondrial inner membrane]
(Canis familiaris)
MRPL40 [mitochondrial inner membrane]
(Gallus gallus)
MRPL40 [mitochondrial inner membrane]
(Sus scrofa)
Cross References
OpenTargets
ENSG00000185608
ENSEMBL
ENSG00000185608
,
ENSP00000333401
,
ENST00000333130
HPA
ENSG00000185608-MRPL40
GeneCards
MRPL40
PRO
Q9NQ50
Pharos - Targets
Q9NQ50
GlyGen
Q9NQ50
PDB
7A5H
,
7OG4
,
8XT2
,
8K2B
,
7A5I
,
7O9K
,
7ODS
,
7OID
,
5OOM
,
7OIB
,
7OIE
,
7PO4
,
6NU2
,
6ZSC
,
7L08
,
8OIT
,
8XT3
,
7A5K
,
7ODT
,
6ZSA
,
7A5F
,
8QU5
,
6I9R
,
8ANY
,
6ZM5
,
7A5G
,
7OF0
,
7PD3
,
3J9M
,
8QSJ
,
7OF5
,
7OF3
,
7QI6
,
7A5J
,
8XT0
,
6VMI
,
7OIC
,
7OIA
,
7OI8
,
7OI7
,
6NU3
,
7O9M
,
5OOL
,
7L20
,
6ZSD
,
6ZSG
,
8XT1
,
6ZSE
,
8OIR
,
3J7Y
,
7OI9
,
6ZSB
,
8K2A
,
7ODR
,
6ZS9
,
6VLZ
,
6ZM6
,
8PK0
,
7OF4
,
7OF2
,
7OF7
,
7QI5
,
7QI4
,
7OF6
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DPK4 NOTCH2NLC
1
NOTCH2NLC [extracellular region]
(R-HSA-9908932)
0.556
3
UniProt:Q7Z3S9 NOTCH2NLA
3
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
NOTCH2NLA(1-?) [extracellular region]
(R-HSA-9911493)
NOTCH2NLA(?-236) [extracellular region]
(R-HSA-9911490)
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.556
3
UniProt:P67809 YBX1
5
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
p-S32,S36-YBX1 [cytosol]
(R-HSA-9736837)
YBX1 [cytosol]
(R-HSA-9736840)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.527
2
UniProt:P62241 RPS8
2
RPS8 [cytosol]
(R-HSA-72385)
RPS8 [nucleoplasm]
(R-HSA-6791203)
0.527
3
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