Reactome | Hh C-terminal fragments are degraded by the proteasome

Hh C-terminal fragments are degraded by the proteasome

Stable Identifier

R-HSA-5362448

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Hh C-terminal fragments are degraded by the proteasome

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After retrotranslocation to the cytosol, Hh-C is degraded by the proteasome (Chen et al, 2011; Huang et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
21357747	Processing and turnover of the Hedgehog protein in the endoplasmic reticulum Jao, C, Rapoport, TA, Tang, HY, Chu, YR, Schulman, S, Huang, CH, Chen, X, Salic, A, Mueller, B, Tukachinsky, H	J. Cell Biol.	2011
23867461	Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum Ye, Y, Chu, YR, Hsiao, HT, Huang, CH, Chen, X	J. Biol. Chem.	2013