SYVN1 ubiquitinates Hh C-terminal fragments

Stable Identifier
R-HSA-5362412
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
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SYVN1 ubiquitinates Hh C-terminal fragments
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SYVN1 ubiquitinates Hh-C as part of the retrotranslocon that targets these Hh fragments for degradation through the ERAD pathway. Both depletion of SYVN1 by siRNA and expression of a catalytically inactive form of the enzyme strongly inhibits Hh-C degradation. Consistent with this, a dominant negative version of SYVN1 abrogates the polyubiquitination of Hh-C as assessed by IP-Western from HEK293 cells (Chen et al, 2011).
Literature References
PubMed ID Title Journal Year
21357747 Processing and turnover of the Hedgehog protein in the endoplasmic reticulum

Chen, X, Tukachinsky, H, Huang, CH, Jao, C, Chu, YR, Tang, HY, Mueller, B, Schulman, S, Rapoport, TA, Salic, A

J. Cell Biol. 2011
Participants
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Output
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as an event of
Catalyst Activity

ubiquitin-protein transferase activity of C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]

Physical Entity
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
SYVN1 ubiquitinates Hh C-terminal fragments (Bos taurus)
SYVN1 ubiquitinates Hh C-terminal fragments (Caenorhabditis elegans)
SYVN1 ubiquitinates Hh C-terminal fragments (Canis familiaris)
SYVN1 ubiquitinates Hh C-terminal fragments (Danio rerio)
SYVN1 ubiquitinates Hh C-terminal fragments (Dictyostelium discoideum)
SYVN1 ubiquitinates Hh C-terminal fragments (Drosophila melanogaster)
SYVN1 ubiquitinates Hh C-terminal fragments (Gallus gallus)
SYVN1 ubiquitinates Hh C-terminal fragments (Mus musculus)
SYVN1 ubiquitinates Hh C-terminal fragments (Rattus norvegicus)
SYVN1 ubiquitinates Hh C-terminal fragments (Schizosaccharomyces pombe)
SYVN1 ubiquitinates Hh C-terminal fragments (Sus scrofa)
SYVN1 ubiquitinates Hh C-terminal fragments (Xenopus tropicalis)
Authored
Rothfels, K  (2014-04-08)
Reviewed
Liu, Y C  (2014-05-16)
Created
Rothfels, K  (2014-04-16)
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