AXL autophosphorylates on Y772 and Y814

Stable Identifier
R-HSA-5357429
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

VEGFA-dependent activation of VEGFR2 causes autophosphorylation and activation of the Axl receptor tyrosine kinase via Src-1:SH2D2A-dependent reaction. Phosphorylation of Axl tyrosine residues 772 and 814 (773 and 815 in mouse) is required for VEGFA-dependent binding of the p85-subunit of PI3K and activation of PI3K (Ruan & Kazlauskas, 2012).

Literature References
PubMed ID Title Journal Year
22327215 Axl is essential for VEGF-A-dependent activation of PI3K/Akt

Ruan, GX, Kazlauskas, A

EMBO J. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created