AXL autophosphorylates on Y772 and Y814

Stable Identifier
R-HSA-5357429
Type
Reaction
Species
Homo sapiens
Compartment
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VEGFA-dependent activation of VEGFR2 causes autophosphorylation and activation of the Axl receptor tyrosine kinase via Src-1:SH2D2A-dependent reaction. Phosphorylation of Axl tyrosine residues 772 and 814 (773 and 815 in mouse) is required for VEGFA-dependent binding of the p85-subunit of PI3K and activation of PI3K (Ruan & Kazlauskas, 2012).

Literature References
PubMed ID Title Journal Year
22327215 Axl is essential for VEGF-A-dependent activation of PI3K/Akt

Ruan, GX, Kazlauskas, A

EMBO J. 2012
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane]

Orthologous Events
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