Signaling by GSK3beta mutants

Stable Identifier
R-HSA-5339716
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Signaling by GSK3beta mutants
Click the image above or here to open this pathway in the Pathway Browser
GSK3beta is subject to in-frame missplicing in CML stem cells resulting in the production of mutant protein that lacks the AXIN and FRAT binding domains. Cells containing this mutant GSK3beta show elevated levels of nuclear beta-catenin and enhanced TCF-dependent reporter activity (Jamieson et al, 2008; Abrahamsson et al, 2009).
Literature References
PubMed ID Title Journal Year
15306667 Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

Weissman, IL, Jones, C, Jamieson, CH, Manz, MG, Gotlib, J, Ailles, LE, Muijtjens, M, Zehnder, JL, Keating, A, Li, K, Dylla, SJ, Sawyers, CL

N. Engl. J. Med. 2004
19237556 Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation

Weissman, IL, Creusot, RS, Newton, IG, Barroga, CF, Abrahamsson, AE, Negrin, RS, Keating, A, Karimi, M, Jones, C, Jamieson, CH, Giles, FJ, Gotlib, J, Zehnder, JL, Geron, I, Durocher, J, Dao, KH

Proc. Natl. Acad. Sci. U.S.A. 2009
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
chronic myeloid leukemia DOID:8552 CML, chronic myelogenous leukemia, no ICD-O subtype (morphologic abnormality), chronic myeloid leukemia, disease (disorder), chronic myeloid leukemia without mention of remission, CML - chronic Myelogenous Leukemia, chronic myeloid leukemia in remission (disorder), Myeloid Leukemia, chronic, CML in Remission, chronic myeloid leukemia in remission, chronic myeloid leukaemia, chronic myeloid leukemia NOS (disorder)
Cross References
BioModels Database
Authored
Rothfels, K  (2014-02-22)
Reviewed
Salahshor, S  (2014-05-12)
Woodgett, J  (2014-05-22)
Created
Rothfels, K  (2014-03-08)
Cite Us!