MAGT1 transports Mg2+ from extracellular region to cytosol

Stable Identifier
R-HSA-5339538
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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MAGT1 transports Mg2+ from extracellular region to cytosol
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Magnesium (Mg2+) is required for the catalytic activity of numerous metalloenzymes within a variety of subcellular organelles. Magnesium transporter protein 1 (MAGT1) is ubiquitously expressed in all human tissues and is upregulated by low Mg2+ concentrations. It is an essential protein in Mg2+ uptake into cells (Zhou & Clapham 2009, Goytain & Quamme 2005).

Literature References
PubMed ID Title Journal Year
19717468 Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development

Zhou, H, Clapham, DE

Proc. Natl. Acad. Sci. U.S.A. 2009
15804357 Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties

Quamme, GA, Goytain, A

BMC Genomics 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

magnesium ion transmembrane transporter activity of MAGT1 [plasma membrane]

Physical Entity
MAGT1 [plasma membrane] (Homo sapiens)
Activity
magnesium ion transmembrane transporter activity (GO:0015095)
Orthologous Events
MAGT1 transports Mg2+ from extracellular region to cytosol (Bos taurus)
MAGT1 transports Mg2+ from extracellular region to cytosol (Caenorhabditis elegans)
MAGT1 transports Mg2+ from extracellular region to cytosol (Canis familiaris)
MAGT1 transports Mg2+ from extracellular region to cytosol (Danio rerio)
MAGT1 transports Mg2+ from extracellular region to cytosol (Dictyostelium discoideum)
MAGT1 transports Mg2+ from extracellular region to cytosol (Drosophila melanogaster)
MAGT1 transports Mg2+ from extracellular region to cytosol (Gallus gallus)
MAGT1 transports Mg2+ from extracellular region to cytosol (Mus musculus)
MAGT1 transports Mg2+ from extracellular region to cytosol (Plasmodium falciparum)
MAGT1 transports Mg2+ from extracellular region to cytosol (Rattus norvegicus)
MAGT1 transports Mg2+ from extracellular region to cytosol (Saccharomyces cerevisiae)
MAGT1 transports Mg2+ from extracellular region to cytosol (Schizosaccharomyces pombe)
MAGT1 transports Mg2+ from extracellular region to cytosol (Sus scrofa)
MAGT1 transports Mg2+ from extracellular region to cytosol (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2014-03-04)
Reviewed
D'Eustachio, P  (2015-02-11)
Created
Jassal, B  (2014-03-04)
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