MAGT1 transports Mg2+ from extracellular region to cytosol

Stable Identifier
R-HSA-5339538
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Magnesium (Mg2+) is required for the catalytic activity of numerous metalloenzymes within a variety of subcellular organelles. Magnesium transporter protein 1 (MAGT1) is ubiquitously expressed in all human tissues and is upregulated by low Mg2+ concentrations. It is an essential protein in Mg2+ uptake into cells (Zhou & Clapham 2009, Goytain & Quamme 2005).

Literature References
PubMed ID Title Journal Year
15804357 Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties

Goytain, A, Quamme, GA

BMC Genomics 2005
19717468 Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development

Zhou, H, Clapham, DE

Proc. Natl. Acad. Sci. U.S.A. 2009
Participants
Participates
Catalyst Activity

magnesium ion transmembrane transporter activity of MAGT1 [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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