Reactome | GMPPB [cytosol]

GMPPB [cytosol]

Stable Identifier

R-HSA-532525

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Mannose-1-phosphate guanyltransferase beta, GMPPB_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of GDP-mannose (Homo sapiens)
        
        GMPPB converts Mannose-1-phosphate to GDP-Mannose (Homo sapiens)
        
        GMPP [cytosol] (Homo sapiens)
        
        GMPPB [cytosol] (Homo sapiens)
        
        GMPPB [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y5P6 GMPPB

Gene Names

GMPPB

Chain

chain:1-360

Reference Genes

BioGPS Gene:29925 GMPPB

COSMIC - genes:GMPPB GMPPB

CTD Gene:29925 GMPPB

dbSNP Gene:29925 GMPPB

ENSEMBL:ENSG00000173540 GMPPB

HGNC:22932 GMPPB

KEGG:hsa:29925 GMPPB

Monarch:29925 GMPPB

NCBI Gene:29925 GMPPB

OMIM:615320 GMPPB

UCSC:Q9Y5P6 GMPPB

Reference Transcript

RefSeq:NM_021971.4 GMPPB

Participates

as a component of

GMPP [cytosol] (Homo sapiens)

Inferred To

mpg1 [cytosol] (Schizosaccharomyces pombe)

GMPPB [cytosol] (Bos taurus)

GMPPB [cytosol] (Caenorhabditis elegans)

GMPPB [cytosol] (Canis familiaris)

GMPPB [cytosol] (Danio rerio)

GMPPB [cytosol] (Dictyostelium discoideum)

GMPPB [cytosol] (Drosophila melanogaster)

GMPPB [cytosol] (Gallus gallus)

GMPPB [cytosol] (Mus musculus)

GMPPB [cytosol] (Rattus norvegicus)

GMPPB [cytosol] (Sus scrofa)

GMPPB [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_068806.2

ENSEMBL

ENST00000308388, ENSP00000311130, ENST00000480687, ENST00000308375, ENSP00000309092, ENSP00000418565, ENSG00000173540

OpenTargets

ENSG00000173540

IntEnz

2.7.7.13

GeneCards

GMPPB

HPA

ENSG00000173540-GMPPB

PRO

Q9Y5P6

Pharos - Targets

Q9Y5P6

GlyGen

Q9Y5P6

Orphanet

GMPPB

HMDB Protein

HMDBP03736

PDB

7D73, 7D74, 7D72

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IVS8 GLYCTK	1	GLYCTK [cytosol] (R-HSA-6799244)	0.556	5
UniProt:Q7L190 DPPA4	1	DPPA4 [nucleoplasm] (R-HSA-452999)	0.556	3
UniProt:O15160 POLR1C	2	POLR1C [cytosol] (R-HSA-1964454) POLR1C [nucleoplasm] (R-HSA-63498)	0.556	3

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