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CYP3A4 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-52639
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Cytochrome P450 3A4 , Quinine 3-monooxygenase, CYPIIIA4, Nifedipine oxidase, NF-25, P450-PCN1
Locations in the PathwayBrowser
Expand all
Drug ADME (Homo sapiens)
Aspirin ADME (Homo sapiens)
CYP2,3 cytochromes hydroxylate ST to 2,3-DHBA (Homo sapiens)
CYP2,3 cytochromes [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2,3 cytochromes hydroxylate ST to 2,5-DHBA (Homo sapiens)
CYP2,3 cytochromes [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
Atorvastatin ADME (Homo sapiens)
CYP3A4 monooxygenates ATV to 2-OH-ATV (Homo sapiens)
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4 monooxygenates ATV to 4-OH-ATV (Homo sapiens)
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4 monooxygenates ATVL to 2-OH-ATVL (Homo sapiens)
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4 monooxygenates ATVL to 4-OH-ATVL (Homo sapiens)
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
Prednisone ADME (Homo sapiens)
CYP3A4 oxidizes PREDN,PREDL (Homo sapiens)
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Aflatoxin activation and detoxification (Homo sapiens)
CYP1A2, 3A4 oxidise AFB1 to AFNBO (Homo sapiens)
CYP1A2,3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (Homo sapiens)
CYP1A2,3A4,3A5,2A13 [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4,5 hydroxylates AFB1 to AFQ1 (Homo sapiens)
CYP3A4,5 [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
CYP3A4 binds CYP3A4 inhibitors (Homo sapiens)
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4:CYP3A4 inhibitors [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4, CYP2B6 bind ritonavir (Homo sapiens)
CYP3A4, CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4,CYP2B6:ritinovir [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4, CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Xenobiotics (Homo sapiens)
CYP3A4 can N-demethylate loperamide (Homo sapiens)
Cytochrome P450 (CYPIIIA4 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4,5 oxidise AFB1 to AFXBO (Homo sapiens)
Cytochrome P450 (CYP3A5 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A7 can 6beta-hydroxylate testosterone (Homo sapiens)
Cytochrome P450 (CYP3A7 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Biosynthesis of DHA-derived SPMs (Homo sapiens)
Biosynthesis of maresins (Homo sapiens)
Biosynthesis of maresin-like SPMs (Homo sapiens)
CYPs hydroxylate DHA to 14(R)-HDHA (Homo sapiens)
CYP1A2,2C8,2C9,2D6,2E1,3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08684 CYP3A4
Gene Names
CYP3A4, CYP3A3
Chain
initiator methionine:, chain:2-503
Reference Genes
BioGPS Gene:1576 CYP3A4
COSMIC (genes):CYP3A4 CYP3A4
CTD Gene:1576 CYP3A4
dbSNP Gene:1576 CYP3A4
ENSEMBL:ENSG00000160868 CYP3A4
HGNC:2637 CYP3A4
Monarch:1576 CYP3A4
NCBI Gene:1576 CYP3A4
OMIM:124010 CYP3A4
UCSC:P08684 CYP3A4
Reference Transcript
RefSeq:NM_017460.5 CYP3A4
RefSeq:NM_001202855.2 CYP3A4
Other Identifiers
11731427_at
11731428_a_at
11731429_x_at
11762588_x_at
1576
17060337
1756_f_at
205998_PM_x_at
205998_x_at
205999_PM_x_at
205999_x_at
208367_PM_x_at
208367_x_at
3063429
3063434
3063466
3063481
3063487
3063502
3063503
3063504
3063506
3063507
3063508
3063509
3063511
3063512
3063513
3063514
3063515
3063516
3063517
3063518
3063520
3063521
3063524
3063525
3063526
8141317
A_24_P389251
A_33_P3251342
D00003_s_at
D00408_s_at
GE88057
GO:0002933
GO:0003824
GO:0004497
GO:0005496
GO:0005506
GO:0005515
GO:0005737
GO:0005783
GO:0005789
GO:0006629
GO:0006631
GO:0006694
GO:0006706
GO:0006766
GO:0006805
GO:0008202
GO:0008203
GO:0008209
GO:0008210
GO:0008289
GO:0008395
GO:0008401
GO:0009822
GO:0016020
GO:0016098
GO:0016491
GO:0016705
GO:0016712
GO:0019825
GO:0019899
GO:0020037
GO:0030343
GO:0034875
GO:0036378
GO:0042178
GO:0042359
GO:0042369
GO:0042572
GO:0042573
GO:0042759
GO:0043226
GO:0043231
GO:0046222
GO:0046872
GO:0050591
GO:0050649
GO:0062181
GO:0062187
GO:0062188
GO:0062189
GO:0070330
GO:0070576
GO:0070989
GO:0101020
GO:0101021
GO:0102320
HMNXSV003035397
HMNXSV003052132
ILMN_1772206
PH_hs_0025855
TC07001649.hg
g13435385_3p_at
g4503228_3p_s_at
g6470134_3p_s_at
Participates
as a component of
CYP3A4:CYP3A4 inhibitors [endoplasmic reticulum membrane] (Homo sapiens)
as an input of
CYP3A4 binds CYP3A4 inhibitors (Homo sapiens)
as a member of
CYP1A2,2C8,2C9,2D6,2E1,3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2,3 cytochromes [endoplasmic reticulum membrane] (Homo sapiens)
CYP1A2,3A4,3A5,2A13 [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4, CYP2B6 [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYPIIIA4 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP1A2,3A4 [endoplasmic reticulum membrane] (Homo sapiens)
CYP3A4,5 [endoplasmic reticulum membrane] (Homo sapiens)
as a candidate of
Cytochrome P450 (CYP3A7 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP3A5 based) [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
CYP3A4 [endoplasmic reticulum membrane]
(Bos taurus)
CYP3A4 [endoplasmic reticulum membrane]
(Canis familiaris)
CYP3A4 [endoplasmic reticulum membrane]
(Danio rerio)
CYP3A4 [endoplasmic reticulum membrane]
(Gallus gallus)
CYP3A4 [endoplasmic reticulum membrane]
(Mus musculus)
CYP3A4 [endoplasmic reticulum membrane]
(Rattus norvegicus)
CYP3A4 [endoplasmic reticulum membrane]
(Sus scrofa)
CYP3A4 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Homologues of CYP3A4 [endoplasmic reticulum membrane]
(Bos taurus)
Homologues of CYP3A4 [endoplasmic reticulum membrane]
(Canis familiaris)
Homologues of CYP3A4 [endoplasmic reticulum membrane]
(Danio rerio)
Homologues of CYP3A4 [endoplasmic reticulum membrane]
(Mus musculus)
Homologues of CYP3A4 [endoplasmic reticulum membrane]
(Rattus norvegicus)
Homologues of CYP3A4 [endoplasmic reticulum membrane]
(Sus scrofa)
Homologues of CYP3A4 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Cross References
ZINC - World Drugs
CP3A4_HUMAN
Guide to Pharmacology - Targets
1337
OpenTargets
ENSG00000160868
ENSEMBL
ENSP00000498939
,
ENST00000651514
ZINC - FDA approved
CP3A4_HUMAN
ZINC - Substances
CP3A4_HUMAN
ZINC - Biogenic
CP3A4_HUMAN
ZINC target
P08684
PRO
P08684
PDB
4D78
,
6BD8
,
4I4G
,
6BDI
,
5VCE
,
5A1P
,
5VCG
,
5A1R
,
2J0D
,
4D75
,
7UAZ
,
7KVO
,
7UFE
,
8EWQ
,
2V0M
,
8EWD
,
4I3Q
,
8SO2
,
3NXU
,
4K9X
,
6BDK
,
4K9W
,
8EWR
,
7KVM
,
4K9V
,
7LXL
,
7UFA
,
7UFC
,
7UF9
,
6BDM
,
4K9U
,
8EWM
,
3UA1
,
8EWP
,
7UFF
,
7UFD
,
7KVN
,
7KVP
,
5G5J
,
4D6Z
,
4I4H
,
7KSA
,
6BCZ
,
6BDH
,
5VCC
,
6OO9
,
5VCD
,
4D7D
,
6OOA
,
6OOB
,
1W0E
,
8EXB
,
7KVI
,
6BD7
,
7KVQ
,
8EWN
,
1W0G
,
6BD6
,
1W0F
,
8EWE
,
1TQN
,
8DYC
,
8SO1
,
5VC0
,
4NY4
,
7KVJ
,
7UFB
,
7KVK
,
7KVS
,
7KS8
,
8EWS
,
8EWL
,
5TE8
,
4K9T
,
3TJS
,
6BD5
,
7UAY
,
7KVH
ZINC - Investigational
CP3A4_HUMAN
ZINC - Metabolites
CP3A4_HUMAN
IntEnz
1.14.14.56
,
1.14.14.55
,
1.14.14.1
HPA
ENSG00000160868-CYP3A4
Pharos - Targets
P08684
ZINC - Predictions - Purchasable
CP3A4_HUMAN
HMDB Protein
HMDBP01018
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
ChEBI:6931 MIDAZOLAM
0.558
3
heme b [ChEBI:26355]
4
heme b [extracellular region]
(R-ALL-2168843)
heme b [endoplasmic reticulum membrane]
(R-ALL-2311355)
heme b [endosome membrane]
(R-ALL-9861434)
heme b [mitochondrial inner membrane]
(R-ALL-9853511)
0.558
3
UniProt:Q6ZQX7-4 Q6ZQX74
0.556
3
UniProt:O15287 FANCG
2
FANCG [nucleoplasm]
(R-HSA-419532)
FANCG [cytosol]
(R-HSA-420788)
0.556
3
UniProt:O00264 PGRMC1
2
PGRMC1 [plasma membrane]
(R-HSA-6806314)
PGRMC1 [specific granule membrane]
(R-HSA-6799648)
0.463
2
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