BoNT/D HC:LC binds SV2A or B or C and GD2 on the target cell surface

Stable Identifier
R-HSA-5250607
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Clostridium botulinum
Compartment
extracellular region, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
BoNT/D HC:LC binds SV2A or B or C and GD2 on the target cell surface
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The botulinum toxin type D disulfide-bonded heavy chain - light chain heterodimer ("dichain") (BoNT/D HC:LC, encoded by the C. botulinum botD gene) binds ganglioside GD2 and synaptic vesicle proteins 2A (SV2A), 2B (SV2B), or 2C (SV2C) on the plasma membrane of a human target cell. In vivo, this process specifically targets synapses at neuromuscular junctions, where toxin association with ganglioside may position it to bind efficiently to SV2A, SV2B, or SV2C when those proteins are exposed at the cell surface by exocytosis (Kroken et al. 2011; Peng et al. 2011).

Literature References
PubMed ID Title Journal Year
21483489 Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors

Peng, L, Tepp, WH, Johnson, EA, Dong, M

PLoS Pathog. 2011
21632541 Novel ganglioside-mediated entry of botulinum neurotoxin serotype D into neurons

Kroken, AR, Karalewitz, AP, Fu, Z, Kim, JJ, Barbieri, JT

J. Biol. Chem. 2011
Participants
Input
Output
Participant Of
hasEvent
Disease
Name Identifier Synonyms
botulism 11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
Authored
Krupa, S  (2006-06-15)
Gopinathrao, G  (2006-06-15)
Reviewed
Ichtchenko, K  (2007-08-03)
Thirunavukkarasu, N  (2014-11-18)
Sharma, S  (2014-11-18)
Created
D'Eustachio, P  (2014-01-29)