Botulinum toxin type D light chain (botD LC), in the cytosol of a target cell, catalyzes the removal of an aminoterminal peptide from vesicle-associated membrane protein 2 (VAMP2). botD LC is a zinc metalloprotease (Arndt et al. 2006; Schiavo et al. 1993; Yamasaki et al. 1994). VAMP2 is associated with the cytosolic face of the target cell synaptic vesicle and is required for vesicle docking and exocytosis. Its cleavage by botulinum toxin blocks synaptic vesicle fusion with the plasma membrane and neurotransmitter release (Sudhof et al, 1993; Sudhof 2004).
Südhof, TC, Niemann, H, Jahn, R, De Camilli, P
Polverino de Laureto, P, Schiavo, G, DasGupta, BR, Montecucco, C, Rossetto, O, Benfenati, F, Catsicas, S
Südhof, TC
Arndt, JW, Christian, T, Stevens, RC, Chai, Q
Fykse, EM, Südhof, TC, Roques, B, Link, E, Yamasaki, S, Baumeister, A, Binz, T, Jahn, R, Cornille, F, Blasi, J
metalloendopeptidase activity of botD LC:Zn2+ [cytosol]
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