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PDE1B [cytosol]
Stable Identifier
R-HSA-52371
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phosphodiesterase 1B, calcium/calmodulin-dependent, Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B , Cam-PDE 1B, 63 kDa Cam-PDE
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Nitric oxide stimulates guanylate cyclase (Homo sapiens)
cGMP effects (Homo sapiens)
cGMP is degraded by PDEs (Homo sapiens)
cGMP phosphodiesterases [cytosol] (Homo sapiens)
Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
PDE1B [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
Cam-PDE 1 activation (Homo sapiens)
Calmodulin activates Cam-PDE 1 (Homo sapiens)
PDE1 dimers [cytosol] (Homo sapiens)
Cam-PDE 1B homodimer [cytosol] (Homo sapiens)
PDE1B [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Ca-dependent events (Homo sapiens)
CaM pathway (Homo sapiens)
Calmodulin induced events (Homo sapiens)
Cam-PDE 1 activation (Homo sapiens)
Calmodulin activates Cam-PDE 1 (Homo sapiens)
PDE1 dimers [cytosol] (Homo sapiens)
Cam-PDE 1B homodimer [cytosol] (Homo sapiens)
PDE1B [cytosol] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
cAMP degradation by Phosphodiesterases (Homo sapiens)
cAMP PDEs [cytosol] (Homo sapiens)
Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
PDE1B [cytosol] (Homo sapiens)
General
Can hydrolyze both cAMP and cGMP
External Reference Information
External Reference
UniProt:Q01064 PDE1B
Gene Names
PDE1B, PDE1B1, PDES1B
Chain
chain:1-536
Reference Genes
BioGPS Gene:5153 PDE1B
COSMIC (genes):PDE1B PDE1B
CTD Gene:5153 PDE1B
dbSNP Gene:5153 PDE1B
ENSEMBL:ENSG00000123360 PDE1B
HGNC:8775 PDE1B
KEGG:hsa:5153 PDE1B
Monarch:5153 PDE1B
NCBI Gene:5153 PDE1B
OMIM:171891 PDE1B
UCSC:Q01064 PDE1B
Reference Transcript
RefSeq:NM_001288769.1 PDE1B
RefSeq:NM_000924.3 PDE1B
RefSeq:NM_001315535.1 PDE1B
RefSeq:NM_001165975.2 PDE1B
RefSeq:NM_001315534.1 PDE1B
RefSeq:NM_001288768.1 PDE1B
Other Identifiers
11728721_x_at
11747490_a_at
11749712_a_at
11755209_a_at
16752103
206444_PM_at
206444_at
3416652
3416653
3416655
3416656
3416661
3416662
3416663
3416666
3416667
3416668
3416669
3416670
3416671
3416672
3416673
3416674
3416675
3416676
3416677
3416678
3416679
3416680
3416682
3416685
3416686
3416687
38921_at
5153
7955943
A_23_P139585
GE62088
GE80175
GO:0001975
GO:0003824
GO:0004112
GO:0004114
GO:0004115
GO:0004117
GO:0005515
GO:0005516
GO:0005737
GO:0005829
GO:0007165
GO:0007626
GO:0008081
GO:0008542
GO:0016787
GO:0019933
GO:0030154
GO:0030224
GO:0036006
GO:0042420
GO:0042428
GO:0043025
GO:0046872
GO:0047555
GO:0048101
GO:0050877
GO:0097011
HMNXSV003038808
ILMN_1805098
PH_hs_0026767
TC12000468.hg
U56976_at
g4505676_3p_at
Participates
as a member of
Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
as a component of
Cam-PDE 1B homodimer [cytosol] (Homo sapiens)
Other forms of this molecule
activated PDE1B [cytosol]
Inferred To
Homologues of activated PDE1B [cytosol]
(Dictyostelium discoideum)
Homologues of activated PDE1B [cytosol]
(Plasmodium falciparum)
PDE1B [cytosol]
(Bos taurus)
activated PDE1B [cytosol]
(Caenorhabditis elegans)
activated PDE1B [cytosol]
(Canis familiaris)
activated PDE1B [cytosol]
(Dictyostelium discoideum)
activated PDE1B [cytosol]
(Drosophila melanogaster)
activated PDE1B [cytosol]
(Gallus gallus)
activated PDE1B [cytosol]
(Mus musculus)
activated PDE1B [cytosol]
(Plasmodium falciparum)
activated PDE1B [cytosol]
(Rattus norvegicus)
activated PDE1B [cytosol]
(Sus scrofa)
activated PDE1B [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000915.1
,
NP_001302463.1
,
NP_001302464.1
,
NP_001159447.1
,
NP_001275697.1
,
NP_001275698.1
Guide to Pharmacology - Targets
1295
ENSEMBL
ENST00000243052
,
ENSP00000243052
,
ENSP00000448519
,
ENST00000550620
OpenTargets
ENSG00000123360
HPA
ENSG00000123360-PDE1B
ZINC - Substances
PDE1B_HUMAN
ZINC target
Q01064
PRO
Q01064
Pharos - Targets
Q01064
ZINC - Predictions - Purchasable
PDE1B_HUMAN
HMDB Protein
HMDBP00576
PDB
5UOY
,
5UP0
,
4NPW
,
1TAZ
,
5B25
,
4NPV
,
5W6E
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NUX5 POT1
1
POT1 [nucleoplasm]
(R-HSA-174890)
0.508
2
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