tetX HC:LC binds target cell-surface gangliosides

Stable Identifier
R-HSA-5228407
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Clostridium tetani
Compartment
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Tetanus toxin disulfide-bonded heavy chain - light chain dimer (tetX HC:LC) binds gangliosides on the plasma membrane of a human target cell (Chen et al. 2009; Deinhardt et al. 2006).

Literature References
PubMed ID Title Journal Year
19602728 Gangliosides as high affinity receptors for tetanus neurotoxin

Chen, C, Fu, Z, Kim, JJ, Barbieri, JT, Baldwin, MR

J. Biol. Chem. 2009
16880274 Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1

Deinhardt, K, Berninghausen, O, Willison, HJ, Hopkins, CR, Schiavo, G

J. Cell Biol. 2006
Participants
Participates
Disease
Name Identifier Synonyms
tetanus DOID:11338 clostridial tetanus, Tetanus (disorder), Infection due to Clostridium tetani (disorder)
Authored
Reviewed
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