TeNT HC transports TeNT LC from target cell endosome membrane into cytosol

Stable Identifier
R-HSA-5228406
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Clostridium tetani
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Acidification of the vesicle containing tetanus toxin disulfide-bonded heavy chain - light chain dimer (TeNT HC:LC) is inferred to cause a conformational change in the toxin dimer, allowing the HC part of the toxin to function as a channel through which its LC part is extruded into the neuronal cytosol (Montal 2010).

Literature References
PubMed ID Title Journal Year
20233039 Botulinum neurotoxin: a marvel of protein design

Montal, M

Annu. Rev. Biochem. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein transmembrane transporter activity of TeNT:gangliosides [endocytic vesicle membrane]
Physical Entity
Activity
This event is regulated
Disease
Name Identifier Synonyms
tetanus 11338 clostridial tetanus, Tetanus (disorder), Infection due to Clostridium tetani (disorder)
Authored
Reviewed
Created
Cite Us!