TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine

Stable Identifier
R-HSA-5220990
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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As inferred from mouse, TET1, TET2, and TET3 oxidize 5-hydroxymethylcytosine (5-hmC) in DNA using molecular oxygen and 2-oxoglutarate to yield 5-formylcytosine (5-fC), carbon dioxide, and succinate.

Literature References
PubMed ID Title Journal Year
23727577 A mechanistic overview of TET-mediated 5-methylcytosine oxidation

Ponnaluri, VK, Maciejewski, JP, Mukherji, M

Biochem. Biophys. Res. Commun. 2013
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
methylcytosine dioxygenase activity of TET1,2,3 [nucleoplasm]
Physical Entity
Activity
Inferred From
Authored
Reviewed
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