TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine

Stable Identifier
R-HSA-5220990
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine
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As inferred from mouse, TET1, TET2, and TET3 oxidize 5-hydroxymethylcytosine (5-hmC) in DNA using molecular oxygen and 2-oxoglutarate to yield 5-formylcytosine (5-fC), carbon dioxide, and succinate.
Literature References
PubMed ID Title Journal Year
23727577 A mechanistic overview of TET-mediated 5-methylcytosine oxidation

Ponnaluri, VK, Maciejewski, JP, Mukherji, M

Biochem. Biophys. Res. Commun. 2013
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Event Information
Go Biological Process
chromosomal 5-methylcytosine DNA demethylation, oxidation pathway (0141167)
Catalyst Activity

DNA 5-methylcytosine dioxygenase activity of TET1,2,3 [nucleoplasm]

Physical Entity
TET1,2,3 [nucleoplasm] (Homo sapiens)
Activity
DNA 5-methylcytosine dioxygenase activity (GO:0070579)
Inferred From
Tet1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine (Mus musculus)
Authored
May, B  (2013-12-29)
Reviewed
Pfeifer, GP  (2014-01-29)
Mukherji, M  (2014-02-21)
Created
May, B  (2013-12-30)
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