p-6Y-VEGFR2 binds PI3K

Stable Identifier
R-HSA-5218852
Type
Reaction [binding]
Species
Homo sapiens
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Activation of VEGFR2 results in the activation of phosphatidylinositol 3-kinase (PI3K) which plays an important role in regulating endothelial proliferation, migration and survival (Jiang et al. 2000). Activation of PI3K is also essential for VEGF-stimulated nitric oxide (NO) production from endothelial cells via protein kinase B (PKB/AKT) signaling to eNOS (Nitric oxide synthase, endothelial) (Blanes et al. 2007). Upon stimulation by VEGF the p85 regulatory subunit of PI3K is recruited to phosphorylated tyrosine-801 of VEGFR2 (Dayanir et al. 2001).

Literature References
PubMed ID Title Journal Year
10677529 Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

Jiang, BH, Zheng, JZ, Aoki, M, Vogt, PK

Proc. Natl. Acad. Sci. U.S.A. 2000
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