Phosphorylation of S732 in FAK1 changes its conformation making Y407 accessible to Proline tyrosine kinase 2-beta (PTK2B). pY402-PTK2B then triggers the phosphorylation of FAK1 on Y407 (Le Boeuf et al. 2006). Phosphorylation of Y407 is required to recruit paxillin and vinculin to FAK1 and to ensure formation of focal adhesions and cell migration (Le Boeuf et al. 2004).
Houle, F, Sussman, M, Le Boeuf, F, Huot, J
protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:p-Y402-PTK2B [plasma membrane]
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