p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407

Stable Identifier
R-HSA-5218851
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylation of S732 in FAK1 changes its conformation making Y407 accessible to Proline tyrosine kinase 2-beta (PTK2B). pY402-PTK2B then triggers the phosphorylation of FAK1 on Y407 (Le Boeuf et al. 2006). Phosphorylation of Y407 is required to recruit paxillin and vinculin to FAK1 and to ensure formation of focal adhesions and cell migration (Le Boeuf et al. 2004).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:p-Y402-PTK2B [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created