Reactome | p-6Y-VEGFR2 binds FYN

p-6Y-VEGFR2 binds FYN

Stable Identifier

R-HSA-5218824

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

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Tyrosine-1214 phosphorylation allows recruitment of cytoplasmic tyrosine kinase FYN along with NCK to VEGFR2. FYN and NCK associate with each other. This complex mediates phosphorylation of p21-activated protein kinase 2 (PAK2) and subsequent activation of p38MAPK mediating actin reorganization and cell migration (Lamalice et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16966330	Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF Lamalice, L, Houle, F, Huot, J	J. Biol. Chem.	2006

Participants

Input

Output

VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Homo sapiens)

Participant Of

hasEvent

VEGFA-VEGFR2 Pathway

Orthologous Events

p-6Y-VEGFR2 binds FYN (Bos taurus)

p-6Y-VEGFR2 binds FYN (Canis familiaris)

p-6Y-VEGFR2 binds FYN (Danio rerio)

p-6Y-VEGFR2 binds FYN (Mus musculus)

p-6Y-VEGFR2 binds FYN (Rattus norvegicus)

p-6Y-VEGFR2 binds FYN (Sus scrofa)

p-6Y-VEGFR2 binds FYN (Xenopus tropicalis)

Authored

Garapati, P V (2013-08-30)

Reviewed

Welsh, M (2014-05-12)

Berger, P (2014-05-12)

Ballmer-Hofer, K (2014-05-12)

Created

Garapati, P V (2013-12-19)