p-6Y-VEGFR2 binds FYN

Stable Identifier
R-HSA-5218824
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-6Y-VEGFR2 binds FYN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Tyrosine-1214 phosphorylation allows recruitment of cytoplasmic tyrosine kinase FYN along with NCK to VEGFR2. FYN and NCK associate with each other. This complex mediates phosphorylation of p21-activated protein kinase 2 (PAK2) and subsequent activation of p38MAPK mediating actin reorganization and cell migration (Lamalice et al. 2006).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
p-6Y-VEGFR2 binds FYN (Canis familiaris)
p-6Y-VEGFR2 binds FYN (Danio rerio)
p-6Y-VEGFR2 binds FYN (Mus musculus)
p-6Y-VEGFR2 binds FYN (Rattus norvegicus)
p-6Y-VEGFR2 binds FYN (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Ballmer-Hofer, K  (2014-05-12)
Created
Garapati, P V  (2013-12-19)
Cite Us!