p-6Y-VEGFR2 binds FYN

Stable Identifier
R-HSA-5218824
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Tyrosine-1214 phosphorylation allows recruitment of cytoplasmic tyrosine kinase FYN along with NCK to VEGFR2. FYN and NCK associate with each other. This complex mediates phosphorylation of p21-activated protein kinase 2 (PAK2) and subsequent activation of p38MAPK mediating actin reorganization and cell migration (Lamalice et al. 2006).

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