p-6Y-VEGFR2 binds FYN

Stable Identifier
R-HSA-5218824
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
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p-6Y-VEGFR2 binds FYN
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Tyrosine-1214 phosphorylation allows recruitment of cytoplasmic tyrosine kinase FYN along with NCK to VEGFR2. FYN and NCK associate with each other. This complex mediates phosphorylation of p21-activated protein kinase 2 (PAK2) and subsequent activation of p38MAPK mediating actin reorganization and cell migration (Lamalice et al. 2006).

Literature References
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Input
Output
Participates
as an event of
Orthologous Events
p-6Y-VEGFR2 binds FYN (Bos taurus)
p-6Y-VEGFR2 binds FYN (Canis familiaris)
p-6Y-VEGFR2 binds FYN (Danio rerio)
p-6Y-VEGFR2 binds FYN (Gallus gallus)
p-6Y-VEGFR2 binds FYN (Mus musculus)
p-6Y-VEGFR2 binds FYN (Rattus norvegicus)
p-6Y-VEGFR2 binds FYN (Sus scrofa)
p-6Y-VEGFR2 binds FYN (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Ballmer-Hofer, K  (2014-05-12)
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Created
Garapati, P V  (2013-12-19)
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