Reactome | PAK2 autophorylates

PAK2 autophorylates

Stable Identifier

R-HSA-5218814

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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PAK2 undergoes autophosphorylation on serine and threonine residues, which maintains PAK2 in a catalytically active state. PAK is autophosphorylated at several sites but S141 flanking the kinase inhibitor region and T402 within the catalytic domain are the two conserved sites that regulate the catalytic activity (Chong et al. 2001, Gatti et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
11278486	The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity Chong, C, Tan, L, Lim, L, Manser, E	J Biol Chem	2001
10075701	Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation Gatti, A, Huang, Z, Tuazon, PT, Traugh, JA	J Biol Chem	1999