PAK2 autophorylates

Stable Identifier
R-HSA-5218814
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PAK2 undergoes autophosphorylation on serine and threonine residues, which maintains PAK2 in a catalytically active state. PAK is autophosphorylated at several sites but S141 flanking the kinase inhibitor region and T402 within the catalytic domain are the two conserved sites that regulate the catalytic activity (Chong et al. 2001, Gatti et al. 1999).

Literature References
PubMed ID Title Journal Year
10075701 Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation

Gatti, A, Huang, Z, Tuazon, PT, Traugh, JA

J Biol Chem 1999
11278486 The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

Chong, C, Tan, L, Lim, L, Manser, E

J Biol Chem 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created