PAK2 autophorylates

Stable Identifier
R-HSA-5218814
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PAK2 undergoes autophosphorylation on serine and threonine residues, which maintains PAK2 in a catalytically active state. PAK is autophosphorylated at several sites but S141 flanking the kinase inhibitor region and T402 within the catalytic domain are the two conserved sites that regulate the catalytic activity (Chong et al. 2001, Gatti et al. 1999).
Literature References
PubMed ID Title Journal Year
11278486 The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

Manser, E, Lim, L, Chong, C, Tan, L

J Biol Chem 2001
10075701 Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation

Huang, Z, Traugh, JA, Tuazon, PT, Gatti, A

J Biol Chem 1999
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!