Upon stimulation FAK1 (also known as PTK2), in association with Src family kinases (SFKs) phosphorylates paxillin (PXN) at two main sites- tyrosine 31 and tyrosine 118. These phosphorylated sites provides the functional SH2-binding sites for members of the Crk family of SH2-SH3 adaptor proteins (Bellis et al. 1995, Shaller & Schaefer 2001).
Schaefer, EM, Schaller, MD
protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane]
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