PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118

Stable Identifier
R-HSA-5218809
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Upon stimulation FAK1 (also known as PTK2), in association with Src family kinases (SFKs) phosphorylates paxillin (PXN) at two main sites- tyrosine 31 and tyrosine 118. These phosphorylated sites provides the functional SH2-binding sites for members of the Crk family of SH2-SH3 adaptor proteins (Bellis et al. 1995, Shaller & Schaefer 2001).

Literature References
PubMed ID Title Journal Year
11695992 Multiple stimuli induce tyrosine phosphorylation of the Crk-binding sites of paxillin

Schaller, MD, Schaefer, EM

Biochem. J. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created