PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118

Stable Identifier
R-HSA-5218809
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118
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Upon stimulation FAK1 (also known as PTK2), in association with Src family kinases (SFKs) phosphorylates paxillin (PXN) at two main sites- tyrosine 31 and tyrosine 118. These phosphorylated sites provides the functional SH2-binding sites for members of the Crk family of SH2-SH3 adaptor proteins (Bellis et al. 1995, Shaller & Schaefer 2001).

Literature References
PubMed ID Title Journal Year
11695992 Multiple stimuli induce tyrosine phosphorylation of the Crk-binding sites of paxillin

Schaefer, EM, Schaller, MD

Biochem. J. 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane]

Physical Entity
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Canis familiaris)
PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Danio rerio)
PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Gallus gallus)
PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Mus musculus)
PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Rattus norvegicus)
PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Ballmer-Hofer, K  (2014-05-12)
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Created
Garapati, P V  (2013-12-19)
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