PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118

Stable Identifier
R-HSA-5218809
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Upon stimulation FAK1 (also known as PTK2), in association with Src family kinases (SFKs) phosphorylates paxillin (PXN) at two main sites- tyrosine 31 and tyrosine 118. These phosphorylated sites provides the functional SH2-binding sites for members of the Crk family of SH2-SH3 adaptor proteins (Bellis et al. 1995, Shaller & Schaefer 2001).

Literature References
PubMed ID Title Journal Year
11695992 Multiple stimuli induce tyrosine phosphorylation of the Crk-binding sites of paxillin

Schaefer, EM, Schaller, MD

Biochem. J. 2001
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!