FYN autophosphorylates

Stable Identifier
R-HSA-5218806
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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FYN recruited to VEGFR2 is activated; this is required for VEGF-induced actin remodelling and endothelial migration. Once Y531 in the negative regulatory site is dephosphorylated by a phosphatase, FYN undergoes autophosphorylation on Y420 (Yeo et al. 2011).

Literature References
PubMed ID Title Journal Year
20658524 Phosphorylation of Ser 21 in Fyn regulates its kinase activity, focal adhesion targeting, and is required for cell migration

Yeo, MG, Oh, HJ, Cho, HS, Chun, JS, Marcantonio, EE, Song, WK

J. Cell. Physiol. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created