FYN autophosphorylates

Stable Identifier
R-HSA-5218806
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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FYN autophosphorylates
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FYN recruited to VEGFR2 is activated; this is required for VEGF-induced actin remodelling and endothelial migration. Once Y531 in the negative regulatory site is dephosphorylated by a phosphatase, FYN undergoes autophosphorylation on Y420 (Yeo et al. 2011).
Literature References
PubMed ID Title Journal Year
20658524 Phosphorylation of Ser 21 in Fyn regulates its kinase activity, focal adhesion targeting, and is required for cell migration

Yeo, MG, Oh, HJ, Cho, HS, Chun, JS, Marcantonio, EE, Song, WK

J. Cell. Physiol. 2011
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane]

Physical Entity
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
FYN autophosphorylates (Bos taurus)
FYN autophosphorylates (Caenorhabditis elegans)
FYN autophosphorylates (Canis familiaris)
FYN autophosphorylates (Danio rerio)
FYN autophosphorylates (Gallus gallus)
FYN autophosphorylates (Mus musculus)
FYN autophosphorylates (Rattus norvegicus)
FYN autophosphorylates (Sus scrofa)
FYN autophosphorylates (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Ballmer-Hofer, K  (2014-05-12)
Created
Garapati, P V  (2013-12-19)
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