DNMT3A binds Me2sR4-HIST1H4

Stable Identifier
R-HSA-5212679
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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H4R3me2s is a direct binding target for the DNA methyltransferase DNMT3A, which interacts through the ADD domain containing the PHD motif. Loss of the H4R3me2s mark through short hairpin RNA–mediated knockdown of PRMT5 leads to reduced DNMT3A binding, loss of DNA methylation and gene activation (Zhao et al. 2009).

Literature References
PubMed ID Title Journal Year
19234465 PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

Zhao, Q, Rank, G, Tan, YT, Li, H, Moritz, RL, Simpson, RJ, Cerruti, L, Curtis, DJ, Patel, DJ, Allis, CD, Cunningham, JM, Jane, SM

Nat. Struct. Mol. Biol. 2009
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