Anthrax LF cleaves target cell MAP2K2 (MEK2)

Stable Identifier
R-HSA-5211356
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
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Anthrax LF (lethal factor) a zinc metalloprotease (Klimpel et al, 1994) in the target cell cytosol, cleaves MAP2K2 (MEK2, mitogen activated protein kinase kinase 2). While the kinase domain of MAP2K2 is unaffected, an aminoterminal docking domain is disrupted by the cleavage (Duesbery et al. 1998; Vitale et al. 1998).

Literature References
PubMed ID Title Journal Year
9703991 Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages

Vitale, G, Pellizzari, R, Recchi, C, Napolitani, G, Mock, M, Montecucco, C

Biochem. Biophys. Res. Commun. 1998
9563949 Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor

Duesbery, NS, Webb, CP, Leppla, SH, Gordon, VM, Klimpel, KR, Copeland, TD, Ahn, NG, Oskarsson, MK, Fukasawa, K, Paull, KD, Vande Woude, GF

Science 1998
7854123 Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity

Klimpel, KR, Arora, N, Leppla, SH

Mol. Microbiol. 1994
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
metallopeptidase activity of LF [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
anthrax disease 7427
Authored
Reviewed
Created