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LC3 binds the autophagosome membrane Atg5-Atg12 complex
Stable Identifier
R-HSA-5205663
Type
Reaction [binding]
Species
Homo sapiens
Compartment
phagocytic vesicle
ReviewStatus
5/5
Locations in the PathwayBrowser
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Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Mitophagy (Homo sapiens)
PINK1-PRKN Mediated Mitophagy (Homo sapiens)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Homo sapiens)
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The mitochondrion is engulfed after elongation of the isolation membrane. Once the autophagosome is formed, its outer membrane fuses with lysosomes to form the autolysosome. The lysosomal hydrolases (cathepsins and lipases) ultimately degrade the damaged mitochondrion and its associated proteins.
Literature References
PubMed ID
Title
Journal
Year
20712405
Autophagosome formation and molecular mechanism of autophagy
Tanida, I
Antioxid. Redox Signal.
2011
Participants
Input
ATG5:ATG12 [phagocytic vesicle membrane]
(Homo sapiens)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol]
(Homo sapiens)
Output
ATG5:ATG12:LC3:K48polyUB Mitophagy Substrates:SQSTM1 [phagocytic vesicle]
(Homo sapiens)
Participates
as an event of
PINK1-PRKN Mediated Mitophagy (Homo sapiens)
Orthologous Events
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Bos taurus)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Caenorhabditis elegans)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Canis familiaris)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Drosophila melanogaster)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Gallus gallus)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Mus musculus)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Plasmodium falciparum)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Rattus norvegicus)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Sus scrofa)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Xenopus tropicalis)
Authored
Gillespie, ME (2013-11-21)
Reviewed
Chauss, D (2015-09-01)
Kantorow, M (2015-09-01)
Created
Gillespie, ME (2013-12-05)
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