Reactome | DVL2 is phosphorylated by PKC

DVL2 is phosphorylated by PKC

Stable Identifier

R-HSA-5138432

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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WNT5A-dependent phosphorylation of DVL2 by PKC is required for the internalization of FZD4 (Chen et al, 2003; Yu et al, 2007). Endogenous PKC alpha beta and gamma co-immunoprecipitate with myc-DVL2, and phosphorylation increases the association with beta-arrestin 2 (ARRB2) (Chen et al, 2003).

Literature References

PubMed ID	Title	Journal	Year
17199046	Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling Rual, JF, Yu, A, Vidal, M, Kirchhausen, T, Harada, Y, Tamai, K, He, X	Dev. Cell	2007
12958364	Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4 Chen, W, Ahn, S, Caron, MG, Barak, LS, Brown, J, Hu, LA, Lefkowitz, RJ, Nusse, R, Miller, WE, ten Berge, D	Science	2003