DVL2 is phosphorylated by PKC

Stable Identifier
R-HSA-5138432
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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WNT5A-dependent phosphorylation of DVL2 by PKC is required for the internalization of FZD4 (Chen et al, 2003; Yu et al, 2007). Endogenous PKC alpha beta and gamma co-immunoprecipitate with myc-DVL2, and phosphorylation increases the association with beta-arrestin 2 (ARRB2) (Chen et al, 2003).

Literature References
PubMed ID Title Journal Year
12958364 Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4

Chen, W, ten Berge, D, Brown, J, Ahn, S, Hu, LA, Miller, WE, Caron, MG, Barak, LS, Nusse, R, Lefkowitz, RJ

Science 2003
17199046 Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling

Yu, A, Rual, JF, Tamai, K, Harada, Y, Vidal, M, He, X, Kirchhausen, T

Dev. Cell 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein kinase C activity of Activated Protein kinase C (alpha, beta, gamma isoforms) [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created