Acetylated HSF1 dissociates from DNA

Stable Identifier
R-HSA-5082369
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Inducible acetylation of HSF1 at Lys80 within the DNA binding domain results in the disrupted DNA-binding ability thus causing the regulated release of the HSF1 trimers from DNA (Westerheide SD et al. 2009). This acetylation is reversible. Activation of the deacetylase and longevity factor SIRT1 was shown to prolong HSF1 binding to the heat shock promoter of hsp70 gene by maintaining HSF1 in a deacetylated state (Westerheide SD et al. 2009). Thus, the balance between deacetylase activity of SIRT1 and acetyltransferase activity of p300 determine the DNA-binding competent state of HSF1.

Literature References
PubMed ID Title Journal Year
19229036 Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1

Westerheide, SD, Anckar, J, Stevens, SM, Sistonen, L, Morimoto, RI

Science 2009
Participants
Participant Of
Authored
Reviewed
Created
Cite Us!