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HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm]
Stable Identifier
R-HSA-5082373
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
HSF1-dependent transactivation (Homo sapiens)
Attenuation phase (Homo sapiens)
Acetylated HSF1 dissociates from DNA (Homo sapiens)
HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Homo sapiens)
HSF1 acetylation at Lys80 (Homo sapiens)
HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
SIRT1 binds to HSF1 (Homo sapiens)
HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Homo sapiens)
SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Homo sapiens)
HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Homo sapiens)
SIRT1 deacetylates HSF1 (Homo sapiens)
SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Homo sapiens)
HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
9499401
Molecular chaperones as HSF1-specific transcriptional repressors
Shi, Y
,
Morimoto, RI
,
Mosser, DD
Genes Dev.
1998
Participants
components
Ac-K80-HSF1 trimer [nucleoplasm]
(Homo sapiens)
HSF1 target gene [nucleoplasm]
(Homo sapiens)
HSP70:DNAJB1 [nucleoplasm]
(Homo sapiens)
Participates
as a component of
SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Homo sapiens)
as an input of
SIRT1 binds to HSF1 (Homo sapiens)
Acetylated HSF1 dissociates from DNA (Homo sapiens)
as an output of
HSF1 acetylation at Lys80 (Homo sapiens)
Inferred To
HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm]
(Bos taurus)
HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm]
(Caenorhabditis elegans)
HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm]
(Canis familiaris)
HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm]
(Dictyostelium discoideum)
HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm]
(Drosophila melanogaster)
HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm]
(Gallus gallus)
HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm]
(Mus musculus)
HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm]
(Rattus norvegicus)
HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm]
(Saccharomyces cerevisiae)
HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm]
(Schizosaccharomyces pombe)
HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm]
(Sus scrofa)
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