Aquaporins passively transport urea into cells

Stable Identifier
Reaction [transition]
Homo sapiens
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Aquaporin-9 (AQP9) and AQP10 are 6-pass transmembrane proteins that passively transport urea across the plasma membrane through a pore in each subunit of a homotetramer.

Literature References
PubMed ID Title Journal Year
18678926 Compartmentalization of aquaporins in the human intestine

Cohly, HH, Isokpehi, R, Rajnarayanan, RV

Int J Environ Res Public Health 2008
12084581 Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin

Ishibashi, K, Morinaga, T, Kuwahara, M, Sasaki, S, Imai, M

Biochim Biophys Acta 2002
11573934 Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum

Hatakeyama, S, Yoshida, Y, Tani, T, Koyama, Y, Nihei, K, Ohshiro, K, Kamiie, JI, Yaoita, E, Suda, T, Hatakeyama, K, Yamamoto, T

Biochem Biophys Res Commun 2001
18762715 Functional characterization of human aquaporin 9 as a facilitative glycerol carrier

Ohgusu, Y, Ohta, KY, Ishii, M, Katano, T, Urano, K, Watanabe, J, Inoue, K, Yuasa, H

Drug Metab Pharmacokinet 2008
19590626 Altered aquaporin 9 expression and localization in human hepatocellular carcinoma

Padma, S, Smeltz, AM, Banks, PM, Iannitti, DA, McKillop, IH

HPB (Oxford) 2009
11027599 Immunolocalization of AQP9 in liver, epididymis, testis, spleen, and brain

Elkjaer, M, Vajda, Z, Nejsum, LN, Kwon, T, Jensen, UB, Amiry-Moghaddam, M, Fr√łkiaer, J, Nielsen, S

Biochem Biophys Res Commun 2000
10564231 Functional and molecular characterization of the human neutral solute channel aquaporin-9

Tsukaguchi, H, Weremowicz, S, Morton, CC, Hediger, MA

Am J Physiol 1999
Event Information
Catalyst Activity

urea channel activity of AQP9,10 [plasma membrane]

Orthologous Events
Cross References
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