The SALL4 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. SALL4 protein is expressed weakly in the nuclei and cytoplasm of oocytes and day-2 cleavage-stage embryos and is expressed strongly in nuclei of blastocysts (Cauffman et al. 2009) and in induced pluripotent stem cells (Nishino et al. 2010). POU5F1 (OCT4) and STAT3 bind the promoter of the SALL4 gene and enhance transcription (Yang et al. 2010, Bard et al. 2009). SALL4 activates expression of POU5F1, thus forming a self-reinforcing loop (Yang et al. 2010). SALL4 binds the promoter of the SALL4 gene and represses transcription, thus forming a negative autoregulatory loop (Yang et al. 2010). As inferred from mouse the shorter isoform of SALL4, SALL4B is more effective at maintaining pluripotency (Rao et al. 2010).
Tseng, CN, Liu, YH, Li, SS, Lee, TY, Singh, S, Chung, TL
Cauffman, G, Sermon, K, De Rycke, M, Van de Velde, H, Liebaers, I
Rao, S, Yuan, GC, Zhen, S, Roumiantsev, S, Orkin, SH, McDonald, LT
Gelebart, P, Lai, R, Ma, Y, Amin, HM, Bard, JD, Young, LC
Shih, YR, Lee, OK, Yang, AH, Kuo, TK, Lee, CH
Chai, L, Yang, J, Gao, C, Ma, Y
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