Expression of SALL4

Stable Identifier
R-HSA-480520
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of SALL4
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The SALL4 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. SALL4 protein is expressed weakly in the nuclei and cytoplasm of oocytes and day-2 cleavage-stage embryos and is expressed strongly in nuclei of blastocysts (Cauffman et al. 2009) and in induced pluripotent stem cells (Nishino et al. 2010). POU5F1 (OCT4) and STAT3 bind the promoter of the SALL4 gene and enhance transcription (Yang et al. 2010, Bard et al. 2009). SALL4 activates expression of POU5F1, thus forming a self-reinforcing loop (Yang et al. 2010). SALL4 binds the promoter of the SALL4 gene and represses transcription, thus forming a negative autoregulatory loop (Yang et al. 2010). As inferred from mouse the shorter isoform of SALL4, SALL4B is more effective at maintaining pluripotency (Rao et al. 2010).
Literature References
PubMed ID Title Journal Year
16978057 Characterization and gene expression profiling of five new human embryonic stem cell lines derived in Taiwan

Tseng, CN, Liu, YH, Li, SS, Lee, TY, Singh, S, Chung, TL

Stem Cells Dev 2006
18824471 Markers that define stemness in ESC are unable to identify the totipotent cells in human preimplantation embryos

Cauffman, G, Sermon, K, De Rycke, M, Van de Velde, H, Liebaers, I

Hum Reprod 2009
20837710 Differential roles of Sall4 isoforms in embryonic stem cell pluripotency

Rao, S, Yuan, GC, Zhen, S, Roumiantsev, S, Orkin, SH, McDonald, LT

Mol. Cell. Biol. 2010
19151334 Signal transducer and activator of transcription 3 is a transcriptional factor regulating the gene expression of SALL4

Gelebart, P, Lai, R, Ma, Y, Amin, HM, Bard, JD, Young, LC

FASEB J 2009
19489980 Isolation and characterization of stem cells from the human parathyroid gland

Shih, YR, Lee, OK, Yang, AH, Kuo, TK, Lee, CH

Cell Prolif 2009
20505821 A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells

Chai, L, Yang, J, Gao, C, Ma, Y

PLoS One 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
SALL4:SALL4 gene [nucleoplasm] (Homo sapiens)
Active Unit
SALL4 [nucleoplasm]
Positively by
Regulator
POU5F1:STAT3:SALL4 gene [nucleoplasm] (Homo sapiens)
Active Unit
POU5F1 [nucleoplasm]
p-Y705-STAT3 dimer [nucleoplasm]
Authored
May, B  (2010-11-12)
Reviewed
Wang, J  (2014-01-23)
Created
May, B  (2010-01-27)
Cite Us!