PIAS3 SUMOylates RELA with SUMO3

Stable Identifier
R-HSA-4755536
Type
Reaction
Species
Homo sapiens
Compartment
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PIAS3 SUMOylates RELA with SUMO3 at lysine-37, lysine-121, and lysine-122 (Liu et al. 2012, Hendriks et al. 2014). SUMOylation occurs when RELA is bound to NF-kB binding sites on DNA in the nucleus. SUMOylation represses transcriptional activity of RELA and is enhanced by NF-kB activation by TNFalpha.

Literature References
PubMed ID Title Journal Year
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC

Nat. Struct. Mol. Biol. 2014
22649547 NF-?B repression by PIAS3 mediated RelA SUMOylation

Liu, Y, Bridges, R, Wortham, A, Kulesz-Martin, M

PLoS ONE 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS3 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created