Reactome | PIAS3 SUMOylates RELA with SUMO3

PIAS3 SUMOylates RELA with SUMO3

Stable Identifier

R-HSA-4755536

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PIAS3 SUMOylates RELA with SUMO3 at lysine-37, lysine-121, and lysine-122 (Liu et al. 2012, Hendriks et al. 2014). SUMOylation occurs when RELA is bound to NF-kB binding sites on DNA in the nucleus. SUMOylation represses transcriptional activity of RELA and is enhanced by NF-kB activation by TNFalpha.

Literature References

PubMed ID	Title	Journal	Year
22649547	NF-?B repression by PIAS3 mediated RelA SUMOylation Kulesz-Martin, M, Liu, Y, Wortham, A, Bridges, R	PLoS ONE	2012
25218447	Uncovering global SUMOylation signaling networks in a site-specific manner Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M	Nat. Struct. Mol. Biol.	2014