PIAS3 SUMOylates RELA with SUMO3

Stable Identifier
R-HSA-4755536
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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PIAS3 SUMOylates RELA with SUMO3
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PIAS3 SUMOylates RELA with SUMO3 at lysine-37, lysine-121, and lysine-122 (Liu et al. 2012, Hendriks et al. 2014). SUMOylation occurs when RELA is bound to NF-kB binding sites on DNA in the nucleus. SUMOylation represses transcriptional activity of RELA and is enhanced by NF-kB activation by TNFalpha.

Literature References
PubMed ID Title Journal Year
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC

Nat. Struct. Mol. Biol. 2014
22649547 NF-?B repression by PIAS3 mediated RelA SUMOylation

Liu, Y, Bridges, R, Wortham, A, Kulesz-Martin, M

PLoS ONE 2012
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS3 [nucleoplasm]
Physical Entity
PIAS3 [nucleoplasm]
Activity
SUMO transferase activity (0019789)
Orthologous Events
PIAS3 SUMOylates RELA with SUMO3 (Bos taurus)
PIAS3 SUMOylates RELA with SUMO3 (Canis familiaris)
PIAS3 SUMOylates RELA with SUMO3 (Danio rerio)
PIAS3 SUMOylates RELA with SUMO3 (Drosophila melanogaster)
PIAS3 SUMOylates RELA with SUMO3 (Mus musculus)
PIAS3 SUMOylates RELA with SUMO3 (Rattus norvegicus)
PIAS3 SUMOylates RELA with SUMO3 (Sus scrofa)
PIAS3 SUMOylates RELA with SUMO3 (Xenopus tropicalis)
Authored
May, B  (2013-10-20)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-25)