PIAS3 SUMOylates RELA with SUMO3

Stable Identifier
R-HSA-4755536
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PIAS3 SUMOylates RELA with SUMO3
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PIAS3 SUMOylates RELA with SUMO3 at lysine-37, lysine-121, and lysine-122 (Liu et al. 2012, Hendriks et al. 2014). SUMOylation occurs when RELA is bound to NF-kB binding sites on DNA in the nucleus. SUMOylation represses transcriptional activity of RELA and is enhanced by NF-kB activation by TNFalpha.
Literature References
PubMed ID Title Journal Year
22649547 NF-?B repression by PIAS3 mediated RelA SUMOylation

Liu, Y, Bridges, R, Wortham, A, Kulesz-Martin, M

PLoS ONE 2012
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC

Nat. Struct. Mol. Biol. 2014
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Output
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Catalyst Activity

SUMO transferase activity of PIAS3 [nucleoplasm]

Physical Entity
PIAS3 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS3 SUMOylates RELA with SUMO3 (Bos taurus)
PIAS3 SUMOylates RELA with SUMO3 (Drosophila melanogaster)
PIAS3 SUMOylates RELA with SUMO3 (Mus musculus)
PIAS3 SUMOylates RELA with SUMO3 (Rattus norvegicus)
PIAS3 SUMOylates RELA with SUMO3 (Sus scrofa)
Authored
May, B  (2013-10-20)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-25)
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