PIAS3 SUMOylates RELA with SUMO3 at lysine-37, lysine-121, and lysine-122 (Liu et al. 2012, Hendriks et al. 2014). SUMOylation occurs when RELA is bound to NF-kB binding sites on DNA in the nucleus. SUMOylation represses transcriptional activity of RELA and is enhanced by NF-kB activation by TNFalpha.
Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC
Liu, Y, Bridges, R, Wortham, A, Kulesz-Martin, M
SUMO transferase activity of PIAS3 [nucleoplasm]
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