PIAS4 SUMOylates IKBKG with SUMO1

Stable Identifier
R-HSA-4755411
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PIAS4 SUMOylates IKBKG with SUMO1
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PIAS4 SUMOylates IKBKG with SUMO1 at lysine-277 and lysine-309 (Huang et al. 2003, Mabb et al. 2006). SUMOylation occurs in the nucleus when IKBKG is unbound to IKK. The interaction between PIAS4 and IKBKG is increased by genotoxic stress. SUMOylation is independent of ATM.
Literature References
PubMed ID Title Journal Year
16906147 PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress

Mabb, AM, Wuerzberger-Davis, SM, Miyamoto, S

Nat. Cell Biol. 2006
14651848 Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress

Huang, TT, Wuerzberger-Davis, SM, Wu, ZH, Miyamoto, S

Cell 2003
Participants
Input
Output
Participates
as an event of
Catalyst Activity

SUMO transferase activity of PIAS4 [nucleoplasm]

Physical Entity
PIAS4 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS4 SUMOylates IKBKG with SUMO1 (Bos taurus)
PIAS4 SUMOylates IKBKG with SUMO1 (Danio rerio)
PIAS4 SUMOylates IKBKG with SUMO1 (Gallus gallus)
PIAS4 SUMOylates IKBKG with SUMO1 (Mus musculus)
PIAS4 SUMOylates IKBKG with SUMO1 (Rattus norvegicus)
PIAS4 SUMOylates IKBKG with SUMO1 (Sus scrofa)
Authored
May, B  (2013-10-20)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-10-25)
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