Reactome | SRD5A1 dehydrogenates TEST to DHTEST

SRD5A1 dehydrogenates TEST to DHTEST

Stable Identifier

R-HSA-469659

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

Testosterone is converted to 5-alpha-dihydroxytestosterone

ReviewStatus

5/5

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The conversion of testosterone to the most potent androgen, 5-alpha-dihydrotestosterone (DHTEST), is catalyzed by microsomal 5alpha-steroid reductase 1 (SRD5A1) (Andersson & Russell 1990). SRD5A1 is expressed in the prostate and other androgen target sites. Corticotropin (Adrenocorticotropic hormone, ACTH) acts through melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
9536209	A critical review of the origin and control of adrenal androgens McKenna, TJ, Fearon, U, Clarke, D, Cunningham, SK	Baillieres Clin Obstet Gynaecol	1997
2339109	Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases Andersson, S, Russell, DW	Proc Natl Acad Sci U S A	1990