SUMOylation of TOP1 with SUMO1

Stable Identifier
Reaction [transition]
Homo sapiens
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TOP1 is SUMOylated at lysine-117 with SUMO1 (Mao et al. 2000, Mo et al. 2002, Rallabhandi et al. 2002, Impens et al. 2014). SUMOylation is observed in response to the topoisomerase inhibitor camptothecin and causes nucleolar delocalization of TOP1.
Literature References
PubMed ID Title Journal Year
10759568 SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage

Mao, Y, Desai, SD, Sun, M, Liu, LF

Proc. Natl. Acad. Sci. U.S.A. 2000
12149243 Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin

D'Arpa, P, Rallabhandi, P, Hashimoto, K, Moitra, PK, Beck, WT, Mo, YY

J. Biol. Chem. 2002
11709553 Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the protein

Shen, Z, Yu, Y, Beck, WT, Mo, YY

J. Biol. Chem. 2002
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Cossart, P, Radoshevich, L, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
Event Information
Go Biological Process
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]

Orthologous Events
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