PIAS4 SUMOylates PARP1 with SUMO1

Stable Identifier
Reaction [transition]
Homo sapiens
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PIAS4 SUMOylates PARP1 at lysine-203 and lysine-486 with SUMO1 (Martin et al. 2009, Matafora et al. 2009, Messner et al. 2009, Zilio et al. 2013, Impens et al. 2014). SUMOylation abrogates acetylation of PARP1 by p300 (Messner et al. 2009). PARP1 reciprocally poly(ADP-ribose)ylates PIAS4 (Martin et al. 2009). PARP1 is SUMOylated in response to heat shock and SUMOylation is required for full activation of the HSP70.1 promoter (Martin et al 2009).
Literature References
PubMed ID Title Journal Year
19779455 PARP-1 transcriptional activity is regulated by sumoylation upon heat shock

Dejean, A, Zhang, XD, Seeler, JS, Martin, N, Schreiber, V, Schwamborn, K, Guillier, C, Werner, A, Bischof, O

EMBO J. 2009
23871147 DNA-dependent SUMO modification of PARP-1

West, SC, Shah, R, Zilio, N, Williamson, CT, Ulrich, HD, Neuhaus, D, Eustermann, S

DNA Repair (Amst.) 2013
19596686 Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition

Blasi, F, Mori, S, Bachi, A, Matafora, V, D'Amato, A

Mol. Cell Proteomics 2009
19622798 Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function

Hottiger, MO, Müller, S, Schmidt, D, Schär, P, Schuermann, D, Kassner, I, Messner, S, Altmeyer, M

FASEB J. 2009
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Cossart, P, Radoshevich, L, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
Catalyst Activity

SUMO transferase activity of PIAS4 [nucleoplasm]

Orthologous Events
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