Reactome | PIAS4 SUMOylates PARP1 with SUMO1

PIAS4 SUMOylates PARP1 with SUMO1

Stable Identifier

R-HSA-4551604

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PIAS4 SUMOylates PARP1 at lysine-203 and lysine-486 with SUMO1 (Martin et al. 2009, Matafora et al. 2009, Messner et al. 2009, Zilio et al. 2013, Impens et al. 2014). SUMOylation abrogates acetylation of PARP1 by p300 (Messner et al. 2009). PARP1 reciprocally poly(ADP-ribose)ylates PIAS4 (Martin et al. 2009). PARP1 is SUMOylated in response to heat shock and SUMOylation is required for full activation of the HSP70.1 promoter (Martin et al 2009).

Literature References

PubMed ID	Title	Journal	Year
19779455	PARP-1 transcriptional activity is regulated by sumoylation upon heat shock Dejean, A, Zhang, XD, Seeler, JS, Martin, N, Schreiber, V, Schwamborn, K, Guillier, C, Werner, A, Bischof, O	EMBO J.	2009
23871147	DNA-dependent SUMO modification of PARP-1 West, SC, Shah, R, Zilio, N, Williamson, CT, Ulrich, HD, Neuhaus, D, Eustermann, S	DNA Repair (Amst.)	2013
19596686	Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition Blasi, F, Mori, S, Bachi, A, Matafora, V, D'Amato, A	Mol. Cell Proteomics	2009
19622798	Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function Hottiger, MO, Müller, S, Schmidt, D, Schär, P, Schuermann, D, Kassner, I, Messner, S, Altmeyer, M	FASEB J.	2009
25114211	Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli Impens, F, Cossart, P, Radoshevich, L, Ribet, D	Proc. Natl. Acad. Sci. U.S.A.	2014