Reactome | Phosphorylated SHC recruits GRB2:SOS1

Phosphorylated SHC recruits GRB2:SOS1

Stable Identifier

R-HSA-453111

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-2 family signaling (Homo sapiens)
      - Interleukin receptor SHC signaling (Homo sapiens)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
      - Interleukin receptor SHC signaling (Homo sapiens)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)

General

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Shc is tyrosine phosphorylated by an unidentified kinase, creating a docking site for the SH2 domain of Grb2 (Zhu et al. 1994). Grb2 is an adaptor protein believed to be constitutively associated with the guanine nucleotide exchange protein Sos1 (often abbreviated to Sos). Recruitment of the Grb2:Sos1 complex leads to activation of the Ras pathway (Ravichandran & Burakoff 1994) and consequently activation of the MAPK pathway.

Literature References

PubMed ID	Title	Journal	Year
8294403	The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation Ravichandran, KS, Burakoff, SJ	J Biol Chem	1994
1465135	Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases Rozakis-Adcock, M, McGlade, J, Mbamalu, G, Pelicci, G, Daly, R, Li, W, Batzer, A, Thomas, S, Brugge, J, Pelicci, PG	Nature	1992