MAP kinase p38 phosphorylates KSRP

Stable Identifier
R-HSA-451152
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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MAP kinase p38 phosphorylates KSRP
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Activated MAPK p38 alpha and beta phosphorylate KSRP at threonine692. The phosphorylation interferes with the ability of KSRP to bind and destabilize RNA. Thus RNAs become stabilized.
Literature References
PubMed ID Title Journal Year
16364914 p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts

Briata, P, Forcales, SV, Ponassi, M, Corte, G, Chen, CY, Karin, M, Puri, PL, Gherzi, R

Mol Cell 2005
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Catalyst Activity

protein serine/threonine kinase activity of Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol]

Physical Entity
Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Phosphorylation of Khsrp by p38 (Mus musculus)
Authored
May, B  (2009-12-29)
Reviewed
Wilusz, J  (2010-06-29)
Created
May, B  (2009-12-31)
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