MAP kinase p38 phosphorylates KSRP

Stable Identifier
R-HSA-451152
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated MAPK p38 alpha and beta phosphorylate KSRP at threonine692. The phosphorylation interferes with the ability of KSRP to bind and destabilize RNA. Thus RNAs become stabilized.

Literature References
PubMed ID Title Journal Year
16364914 p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts

Briata, P, Forcales, SV, Ponassi, M, Corte, G, Chen, CY, Karin, M, Puri, PL, Gherzi, R

Mol Cell 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created