MAP kinase p38 phosphorylates KSRP

Stable Identifier
R-HSA-451152
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated MAPK p38 alpha and beta phosphorylate KSRP at threonine692. The phosphorylation interferes with the ability of KSRP to bind and destabilize RNA. Thus RNAs become stabilized.

Literature References
PubMed ID Title Journal Year
16364914 p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts

Briata, P, Forcales, SV, Ponassi, M, Corte, G, Chen, CY, Karin, M, Puri, PL, Gherzi, R

Mol Cell 2005
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol]

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