MAP kinase p38 phosphorylates KSRP

Stable Identifier
R-HSA-451152
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MAP kinase p38 phosphorylates KSRP
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated MAPK p38 alpha and beta phosphorylate KSRP at threonine692. The phosphorylation interferes with the ability of KSRP to bind and destabilize RNA. Thus RNAs become stabilized.

Literature References
PubMed ID Title Journal Year
16364914 p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts

Karin, M, Briata, P, Ponassi, M, Forcales, SV, Gherzi, R, Chen, CY, Puri, PL, Corte, G

Mol Cell 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol]

Physical Entity
Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Phosphorylation of Khsrp by p38 (Mus musculus)
Authored
May, B  (2009-12-29)
Reviewed
Wilusz, J  (2010-06-29)
Created
May, B  (2009-12-31)
Cite Us!