Recruitment of the IL-2R gamma chain forms a very stable quaternary complex, capable of signaling. The IL-2 gamma chain further retards IL-2 dissociation so that the rate of IL-2 dissociation from the complex is three times slower than the rate of internalization of the complex (t1/2 55= 45 min vs. 15 min). Therefore, the complex continues to signal as long as it remains on the cell surface.
Stauber, DJ, Horton, PA, Debler, EW, Smith, KA, Wilson, IA
Goriatcheva, N, Boulanger, MJ, Rickert, M, Garcia, KC
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