Reactome | Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit

Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit

Stable Identifier

R-HSA-450063

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Recruitment of the IL-2R gamma chain forms a very stable quaternary complex, capable of signaling. The IL-2 gamma chain further retards IL-2 dissociation so that the rate of IL-2 dissociation from the complex is three times slower than the rate of internalization of the complex (t1/2 55= 45 min vs. 15 min). Therefore, the complex continues to signal as long as it remains on the cell surface.

Literature References

PubMed ID	Title	Journal	Year
16477002	Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor Stauber, DJ, Horton, PA, Debler, EW, Smith, KA, Wilson, IA	Proc Natl Acad Sci U S A	2006
15178252	Compensatory energetic mechanisms mediating the assembly of signaling complexes between interleukin-2 and its alpha, beta, and gamma(c) receptors Goriatcheva, N, Boulanger, MJ, Rickert, M, Garcia, KC	J Mol Biol	2004