Reactome | IL22RA2 binds IL22

IL22RA2 binds IL22

Stable Identifier

R-HSA-448741

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Interleukin-22 receptor subunit alpha-2 (IL22RA2), also known as Interleukin-22 binding protein (IL22BP), is a soluble receptor that binds Interleukin-22 (IL22) within the extracellular region, preventing IL22 from binding to the functional membrane-associated IL22 receptor (Xu et al. 2001, De Moura et al. 2009, Dumoutier et al. 2001, Kotenko et al. 2001). This may play a regulatory role in inflammation.

Literature References

PubMed ID	Title	Journal	Year
11390453	Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22 Dumoutier, L, Lejeune, D, Colau, D, Renauld, JC	J Immunol	2001
11390454	Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity Kotenko, SV, Izotova, LS, Mirochnitchenko, OV, Esterova, E, Dickensheets, H, Donnelly, RP, Pestka, S	J Immunol	2001