IL22RA2 binds IL22

Stable Identifier
R-HSA-448741
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IL22RA2 binds IL22
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Interleukin-22 receptor subunit alpha-2 (IL22RA2), also known as Interleukin-22 binding protein (IL22BP), is a soluble receptor that binds Interleukin-22 (IL22) within the extracellular region, preventing IL22 from binding to the functional membrane-associated IL22 receptor (Xu et al. 2001, De Moura et al. 2009, Dumoutier et al. 2001, Kotenko et al. 2001). This may play a regulatory role in inflammation.

Literature References
PubMed ID Title Journal Year
11390453 Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22

Renauld, JC, Colau, D, Dumoutier, L, Lejeune, D

J Immunol 2001
11390454 Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity

Izotova, LS, Esterova, E, Mirochnitchenko, OV, Dickensheets, H, Donnelly, RP, Kotenko, SV, Pestka, S

J Immunol 2001
Participants
Input
Output
Participates
as an event of
Authored
Jupe, S  (2014-06-04)
Reviewed
Meldal, BH  (2016-01-28)
Created
Jupe, S  (2009-11-25)
Cite Us!