Reactome | Synthesis of dolichyl-phosphate-glucose

Synthesis of dolichyl-phosphate-glucose

Stable Identifier

R-HSA-446214

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose => a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of dolichyl-phosphate-glucose (Homo sapiens)
        
        Synthesis of dolichyl-phosphate-glucose (Homo sapiens)

General

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Dolichyl-phosphate beta-glucosyltransferase (ALG5) associated with the endoplasmic reticulum (ER) membrane catalyzes the reaction of cytosolic UDP-glucose with dolichyl phosphate exposed on the cytosolic face of the ER membrane to form Dolichyl-P-glucose with its glucose moiety oriented toward the cytosol (Imbach T et al, 1999).

Literature References

PubMed ID	Title	Journal	Year
10359825	A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic Imbach, T, Burda, P, Kuhnert, P, Wevers, RA, Aebi, M, Berger, EG, Hennet, T	Proc Natl Acad Sci U S A	1999