Synthesis of dolichyl-phosphate-glucose

Stable Identifier
R-HSA-446214
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Dolichyl-phosphate beta-glucosyltransferase (ALG5) associated with the endoplasmic reticulum (ER) membrane catalyzes the reaction of cytosolic UDP-glucose with dolichyl phosphate exposed on the cytosolic face of the ER membrane to form Dolichyl-P-glucose with its glucose moiety oriented toward the cytosol (Imbach T et al, 1999).

Literature References
PubMed ID Title Journal Year
10359825 A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic

Imbach, T, Burda, P, Kuhnert, P, Wevers, RA, Aebi, M, Berger, EG, Hennet, T

Proc Natl Acad Sci U S A 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
dolichyl-phosphate beta-glucosyltransferase activity of ALG5 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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