Addition of a third glucose to the N-glycan precursor by an ALG10 homologue

Stable Identifier
R-HSA-446194
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The last glucose is added to the N-glycan precursor. This reaction occurs inside the ER lumen and uses Dol-P-Glc as the glucose donor. In yeast, this reaction is catalyzed by ALG10 (Burda P and Aebi M,1998); however, this gene is duplicated in primates (Ciccarelli FD et al, 2005; Table 1), leading to two homologues, ALG10A and ALG10B, and to date there is no clear evidence to say which of these two paralogues (or both) is responsible for catalyzing this reaction in humans. No Congenital Disorders of Glycosylations are known to be associated with either gene.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity of ALG10 homologue [endoplasmic reticulum membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created