Reactome | RORC [nucleoplasm]

RORC [nucleoplasm]

Stable Identifier

R-HSA-446177

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nuclear receptor ROR-gamma, RORG_HUMAN

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External Reference Information

External Reference

UniProt:P51449 RORC

Gene Names

RORC, NR1F3, RORG, RZRG

Chain

chain:1-518

Reference Genes

BioGPS Gene:6097 RORC

COSMIC (genes):RORC RORC

CTD Gene:6097 RORC

dbSNP Gene:6097 RORC

ENSEMBL:ENSG00000143365 RORC

HGNC:10260 RORC

KEGG:hsa:6097 RORC

Monarch:6097 RORC

NCBI Gene:6097 RORC

OMIM:602943 RORC

UCSC:P51449 RORC

Reference Transcript

Participates

as a member of

as an output of

Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of RORC (Homo sapiens)

Inferred To

RORC [nucleoplasm] (Bos taurus)

RORC [nucleoplasm] (Canis familiaris)

RORC [nucleoplasm] (Gallus gallus)

RORC [nucleoplasm] (Sus scrofa)

nhr-23 [nucleoplasm] (Caenorhabditis elegans)

Rorc [nucleoplasm] (Mus musculus)

Rorc [nucleoplasm] (Rattus norvegicus)

rorab [nucleoplasm] (Danio rerio)

Homologues of RORC [nucleoplasm] (Danio rerio)

Hr3 [nucleoplasm] (Drosophila melanogaster)

roraa [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_001001523.1, NP_005051.2

Guide to Pharmacology - Targets

600

OpenTargets

ENSG00000143365

ENSEMBL

ENSG00000143365, ENSP00000327025, ENST00000318247, ENST00000356728, ENSP00000349164

ZINC - FDA approved

RORG_HUMAN

ZINC - Substances

RORG_HUMAN

ZINC - Biogenic

RORG_HUMAN

ZINC target

P51449

PRO

P51449

PDB

7W3P, 6TLQ, 6T4I, 6NAD, 3L0J, 6J3N, 4WPF, 8XU5, 5NTQ, 6Q2W, 5K3M, 6R7K, 5IZ0, 6TLT, 6T4T, 5NTI, 6B30, 6T4K, 6LO9, 5APH, 5NI8, 6B31, 6TLM, 5YP6, 6CN6, 6FGQ, 6E3G, 7XQE, 5G45, 6NWS, 4S14, 5NIB, 6NWT, 5K38, 6P9F, 5K74, 4ZOM, 6Q7H, 4ZJR, 7W3Q, 8GXP, 4NB6, 6SAL, 5LWP, 6T50, 5W4R, 5NTN, 6R7A, 6T4J, 7QP4, 5G42, 6E3E, 6LOA, 5NU1, 6BR2, 5W4V, 6T4U, 5YP5, 6SLZ, 5UFO, 6XFV, 5AYG, 7NEC, 5C4T, 5NI7, 6T4W, 3KYT, 5VB6, 5APJ, 6FZU, 8FB1, 6T4X, 6G07, 5VB5, 6ESN, 4YPQ, 5X8Q, 7NP6, 6BN6, 7JYM, 7LUK, 5NTK, 7KXE, 6W9I, 5NTW, 5C4O, 7KXF, 6O98, 5K3N, 5M96, 4WLB, 8FAV, 5NTP, 6BR3, 6Q6O, 5VB3, 3B0W, 7OFK, 6B33, 5NI5, 7OFI, 6R7J, 4YMQ, 4NIE, 6G05, 5IXK, 6CVH, 5G46, 6T4Y, 7JTM, 6Q7A, 7KQJ, 5VQL, 6NWU, 6U25, 7JH2, 6T4G, 4QM0, 6VSW, 6Q6M, 5EJV, 5UHI, 7KXD, 3L0L, 7E3M, 5C4S, 6W9H, 6LOB, 6VQF, 5G43, 6O3Z, 5ETH, 8FB2, 7NPC, 5C4U, 6CN5, 5G44, 6UCG, 6LOC, 5K3L, 4XT9, 4WQP, 5VB7, 5UFR, 7KCO, 5APK, 5VQK, 7JTW, 5ZA1, 6XAE, 5K6E, 6A22, 6J1L, 6IVX, 7NP5, 4ZJW

ZINC - Metabolites

RORG_HUMAN

HPA

ENSG00000143365-RORC

GeneCards

RORC

Pharos - Targets

P51449

Orphanet

RORC

ZINC - Predictions - Purchasable

RORG_HUMAN

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.556	3
UniProt:O08785 Clock	6	p-T451,T461-Clock [nucleoplasm] (R-MMU-9920668) Clock [cytosol] (R-MMU-508720) p-T451,T461-Clock [cytosol] (R-MMU-9920658) p-S-Clock [nucleoplasm] (R-MMU-508670) p-T451,T461,S440,S441,S446-Clock [nucleoplasm] (R-MMU-9920662) p-S,T451,T461,S440,S441,S446-Clock [nucleoplasm] (R-MMU-9927976)	0.508	2
UniProt:Q9WTL8 Arntl	7	p-S97-Bmal1 [nucleoplasm] (R-MMU-9920676) Arntl [cytosol] (R-MMU-508660) p-S97-Bmal1 [cytosol] (R-MMU-9912402) p-S-Arntl [nucleoplasm] (R-MMU-508690) Bmal1 [nucleoplasm] (R-MMU-9634872) Arntl [nucleoplasm] (R-MMU-9769624) p-S97,Ac-544-Bmal1 [nucleoplasm] (R-MMU-9920664)	0.508	2

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