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HCAR3 [plasma membrane]
Stable Identifier
R-HSA-444718
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Niacin receptor 2, NIACR2, NIAR2_HUMAN, GPR109B, HM74B
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR3:HCAR3 ligands [plasma membrane] (Homo sapiens)
HCAR3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR3:HCAR3 ligands [plasma membrane] (Homo sapiens)
HCAR3 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR3:HCAR3 ligands [plasma membrane] (Homo sapiens)
HCAR3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR3:HCAR3 ligands [plasma membrane] (Homo sapiens)
HCAR3 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR3:HCAR3 ligands [plasma membrane] (Homo sapiens)
HCAR3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR3:HCAR3 ligands [plasma membrane] (Homo sapiens)
HCAR3 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Hydroxycarboxylic acid-binding receptors (Homo sapiens)
HCAR3 binds HCAR3 ligands (Homo sapiens)
HCAR3 [plasma membrane] (Homo sapiens)
HCAR3:HCAR3 ligands [plasma membrane] (Homo sapiens)
HCAR3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49019 HCAR3
Gene Names
HCAR3, GPR109B, HCA3, HM74B, NIACR2
Chain
chain:1-387
Reference Genes
BioGPS Gene:8843 HCAR3
COSMIC (genes):HCAR3 HCAR3
CTD Gene:8843 HCAR3
dbSNP Gene:8843 HCAR3
ENSEMBL:ENSG00000255398 HCAR3
HGNC:16824 HCAR3
KEGG:hsa:8843 HCAR3
Monarch:8843 HCAR3
NCBI Gene:8843 HCAR3
OMIM:606039 HCAR3
UCSC:P49019 HCAR3
Reference Transcript
RefSeq:NM_006018.2 HCAR3
Other Identifiers
11722615_s_at
11724835_s_at
16771801
205220_PM_at
205220_at
3475785
3475786
3475788
3475789
3475791
3475796
3475797
3475798
3475799
3475800
3475801
3475802
3475803
3475804
3475805
34951_at
7967322
8843
A_23_P64721
D10923_at
GE57047
GO:0004930
GO:0005886
GO:0007186
GO:0016020
GO:0030054
GO:0060089
GO:0070553
HMNXSV003009215
ILMN_1677693
ILMN_1791138
PH_hs_0040248
TC12002079.hg
g5174460_3p_at
Participates
as an input of
HCAR3 binds HCAR3 ligands (Homo sapiens)
as a component of
HCAR3:HCAR3 ligands [plasma membrane] (Homo sapiens)
Inferred To
hcar1-4 [plasma membrane]
(Danio rerio)
HCAR2 [plasma membrane]
(Canis familiaris)
HCAR2 [plasma membrane]
(Sus scrofa)
Hcar2 [plasma membrane]
(Mus musculus)
Hcar2 [plasma membrane]
(Rattus norvegicus)
HCAR3 [plasma membrane]
(Bos taurus)
Cross References
RefSeq
NP_006009.2
Guide to Pharmacology - Targets
313
ENSEMBL
ENST00000528880
,
ENSP00000436714
OpenTargets
ENSG00000255398
ZINC - Substances
HCAR3_HUMAN
ZINC target
P49019
PRO
P49019
PDB
8IHK
,
8IHJ
ZINC - Investigational
HCAR3_HUMAN
HPA
ENSG00000255398-HCAR3
Pharos - Targets
P49019
ZINC - Predictions - Purchasable
HCAR3_HUMAN
HMDB Protein
HMDBP02390
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