HCAR3 binds HCAR3 ligands

Stable Identifier
R-HSA-3296309
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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HCAR3 binds HCAR3 ligands
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HCAR3 (GPR109B) is activated by 3-hydroxyoctanoic acid (3HO) (Ahmed et al. 2009) and nicotinic acid (niacin) (Wise et al. 2003). 3HO is an intermediate of fatty acid beta-oxidation. Under conditions of increased beta-oxidation flux, such as during starvation, under a ketogenic diet, or in patients with diabetic ketoacidosis, 3HO plasma concentrations are sufficient to activate the HCAR3 receptor (Costa et al. 1998, Jones et al. 2002, Ahmed et al. 2009).
Literature References
PubMed ID Title Journal Year
19561068 Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis

Ahmed, K, Tunaru, S, Langhans, CD, Hanson, J, Michalski, CW, Kölker, S, Jones, PM, Okun, JG, Offermanns, S

J. Biol. Chem. 2009
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Orthologous Events
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HCAR3 binds HCAR3 ligands (Sus scrofa)
Authored
Jupe, S  (2013-04-18)
Reviewed
D'Eustachio, P  (2013-05-17)
Created
Jupe, S  (2013-04-18)
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