Reactome | HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively

HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively

Stable Identifier

R-HSA-444126

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively

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Carrier-mediated urea transport allows rapid urea movement across the cell membrane, which is particularly important in the process of urinary concentration and for rapid urea equilibrium in non-renal tissues. Two carriers exist in humans, HUT2 which is renal-specific (Olives B et al, 1996) and HUT11, which is erythrocyte-specific (Olives B et al, 1994).

Literature References

PubMed ID	Title	Journal	Year
8647271	Molecular characterization of a new urea transporter in the human kidney Olivès, B, Matassi, G, Bailly, P, Cartron, JP, Martial, S, Rousselet, G, Mattéi, MG, Ripoche, P	FEBS Lett	1996
7989337	Cloning and functional expression of a urea transporter from human bone marrow cells Olives, B, Cartron, JP, Bailly, P, Rousselet, G, Hediger, MA, Neau, P, Ripoche, P	J Biol Chem	1994