HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively

Stable Identifier
R-HSA-444126
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Carrier-mediated urea transport allows rapid urea movement across the cell membrane, which is particularly important in the process of urinary concentration and for rapid urea equilibrium in non-renal tissues. Two carriers exist in humans, HUT2 which is renal-specific (Olives B et al, 1996) and HUT11, which is erythrocyte-specific (Olives B et al, 1994).

Literature References
PubMed ID Title Journal Year
7989337 Cloning and functional expression of a urea transporter from human bone marrow cells

Olives, B, Neau, P, Bailly, P, Hediger, MA, Rousselet, G, Cartron, JP, Ripoche, P

J Biol Chem 1994
8647271 Molecular characterization of a new urea transporter in the human kidney

Olivès, B, Martial, S, Mattéi, MG, Matassi, G, Rousselet, G, Ripoche, P, Cartron, JP, Bailly, P

FEBS Lett 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
urea transmembrane transporter activity of Urea transporters [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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