SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The amino acid glycine plays an important role in neurotransmission. Its action is terminated by rapid re-uptake into the pre-synaptic terminal or surrounding glial cells. This re-uptake is mediated by the sodium- and chloride-dependent glycine transporters 1 and 2 (GLYT1 and GLYT2 respectively). GLYT1 is encoded by the human gene SLC6A9 and is expressed in the brain, liver, kidney, pancreas, lung and placenta (Kim KM et al, 1994). GLYT2 is encoded by the human gene SLC6A5 and is predominantly expressed in the medulla (Morrow JA et al, 1998). Defects in SLC6A5 cause startle disease (STHE or hyperekplexia). STHE is is a human neurological disorder characterized by an excessive startle response (Rees MI et al, 2006).
Literature References
PubMed ID Title Journal Year
9845349 Molecular cloning and functional expression of the human glycine transporter GlyT2 and chromosomal localisation of the gene in the human genome

Dunbar, DR, Morrow, JA, Hill, DR, Shahid, M, Walker, GB, Collie, IT

FEBS Lett 1998
8183239 Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes

Caron, MG, Seldin, MF, Giros, B, Han, H, Yang-Feng, TL, Kingsmore, SF, Godinot, N, Kim, KM

Mol Pharmacol 1994
16751771 Mutations in the gene encoding GlyT2 (SLC6A5) define a presynaptic component of human startle disease

Rees, MI, Smart, TG, Zuberi, SM, Thomas, P, Owen, MJ, Chung, SK, Abbott, KJ, Tijssen, MA, Shiang, R, Supplisson, S, van den Maagdenberg, AM, Armstrong, L, Harvey, K, Duguid, IC, Harvey, RJ, Beatty, S, Pearce, BR, Graham, GE, Stephenson, JB

Nat Genet 2006
Catalyst Activity

glycine:sodium symporter activity of SLC6A5,9 [plasma membrane]

Orthologous Events
Cite Us!